CSMT1_HUMAN
ID CSMT1_HUMAN Reviewed; 132 AA.
AC Q4G0I0; Q96RZ0;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2005, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Protein CCSMST1;
DE Flags: Precursor;
GN Name=CCSMST1; Synonyms=C16orf91;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11157797; DOI=10.1093/hmg/10.4.339;
RA Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C.,
RA Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.;
RT "Sequence, structure and pathology of the fully annotated terminal 2 Mb of
RT the short arm of human chromosome 16.";
RL Hum. Mol. Genet. 10:339-352(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CCSMST1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK61280.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EAW85657.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE006467; AAK61280.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CH471112; EAW85657.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC092497; AAH92497.1; -; mRNA.
DR CCDS; CCDS61789.1; -.
DR RefSeq; NP_001258980.1; NM_001272051.1.
DR AlphaFoldDB; Q4G0I0; -.
DR BioGRID; 129712; 7.
DR IntAct; Q4G0I0; 2.
DR STRING; 9606.ENSP00000413100; -.
DR PhosphoSitePlus; Q4G0I0; -.
DR BioMuta; C16orf91; -.
DR EPD; Q4G0I0; -.
DR jPOST; Q4G0I0; -.
DR MassIVE; Q4G0I0; -.
DR MaxQB; Q4G0I0; -.
DR PaxDb; Q4G0I0; -.
DR PeptideAtlas; Q4G0I0; -.
DR PRIDE; Q4G0I0; -.
DR ProteomicsDB; 62105; -.
DR TopDownProteomics; Q4G0I0; -.
DR Antibodypedia; 62620; 5 antibodies from 4 providers.
DR DNASU; 283951; -.
DR Ensembl; ENST00000442039.3; ENSP00000413100.2; ENSG00000174109.5.
DR GeneID; 283951; -.
DR KEGG; hsa:283951; -.
DR MANE-Select; ENST00000442039.3; ENSP00000413100.2; NM_001272051.2; NP_001258980.1.
DR UCSC; uc002clr.4; human.
DR CTD; 283951; -.
DR GeneCards; C16orf91; -.
DR HGNC; HGNC:27558; C16orf91.
DR HPA; ENSG00000174109; Low tissue specificity.
DR neXtProt; NX_Q4G0I0; -.
DR OpenTargets; ENSG00000174109; -.
DR PharmGKB; PA164716853; -.
DR VEuPathDB; HostDB:ENSG00000174109; -.
DR eggNOG; ENOG502S8XX; Eukaryota.
DR GeneTree; ENSGT00510000049652; -.
DR HOGENOM; CLU_142479_1_0_1; -.
DR InParanoid; Q4G0I0; -.
DR OMA; LIIWCYL; -.
DR OrthoDB; 1625962at2759; -.
DR PhylomeDB; Q4G0I0; -.
DR TreeFam; TF343850; -.
DR PathwayCommons; Q4G0I0; -.
DR SignaLink; Q4G0I0; -.
DR BioGRID-ORCS; 283951; 7 hits in 968 CRISPR screens.
DR GenomeRNAi; 283951; -.
DR Pharos; Q4G0I0; Tdark.
DR PRO; PR:Q4G0I0; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q4G0I0; protein.
DR Bgee; ENSG00000174109; Expressed in upper arm skin and 179 other tissues.
DR ExpressionAtlas; Q4G0I0; baseline and differential.
DR Genevisible; Q4G0I0; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR023248; CCSMST1.
DR InterPro; IPR029160; CCSMST1_fam.
DR PANTHER; PTHR35268; PTHR35268; 1.
DR Pfam; PF15013; CCSMST1; 1.
DR PRINTS; PR02042; CCSMST1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..15
FT /evidence="ECO:0000255"
FT CHAIN 16..132
FT /note="Protein CCSMST1"
FT /id="PRO_0000348602"
FT TOPO_DOM 16..78
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..132
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 29..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 110..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..44
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..132
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 132 AA; 15004 MW; 464B901789CC8A40 CRC64;
MNRVLCAPAA GAVRALRLIG WASRSLHPLP GSRDRAHPAA EEEDDPDRPI EFSSSKANPH
RWSVGHTMGK GHQRPWWKVL PLSCFLVALI IWCYLREESE ADQWLRQVWG EVPEPSDRSE
EPETPAAYRA RT
