CSN10_ASHGO
ID CSN10_ASHGO Reviewed; 553 AA.
AC Q75AS3;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=COP9 signalosome complex subunit 10;
GN Name=RRI2; Synonyms=CSN10; OrderedLocusNames=ADL153W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Component of the COP9 signalosome (CSN) complex that acts as
CC an regulator of the ubiquitin (Ubl) conjugation pathway by mediating
CC the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-
CC protein ligase complexes. The CSN complex is involved in the regulation
CC of the mating pheromone response (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of a COP9 signalosome-like (CSN) complex.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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DR EMBL; AE016817; AAS51767.1; -; Genomic_DNA.
DR RefSeq; NP_983943.1; NM_209296.1.
DR AlphaFoldDB; Q75AS3; -.
DR STRING; 33169.AAS51767; -.
DR EnsemblFungi; AAS51767; AAS51767; AGOS_ADL153W.
DR GeneID; 4620085; -.
DR KEGG; ago:AGOS_ADL153W; -.
DR eggNOG; ENOG502RXR9; Eukaryota.
DR HOGENOM; CLU_031729_0_0_1; -.
DR InParanoid; Q75AS3; -.
DR OMA; DFMMSDD; -.
DR Proteomes; UP000000591; Chromosome IV.
DR GO; GO:0008180; C:COP9 signalosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000338; P:protein deneddylation; IBA:GO_Central.
DR InterPro; IPR037750; COPS2.
DR InterPro; IPR000717; PCI_dom.
DR PANTHER; PTHR10678:SF3; PTHR10678:SF3; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT CHAIN 1..553
FT /note="COP9 signalosome complex subunit 10"
FT /id="PRO_0000121021"
FT DOMAIN 298..474
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT REGION 21..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..42
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 553 AA; 61738 MW; 8CA43C373E9E4106 CRC64;
MSEGDAYEDF MMSEDEEMHY AEMEEDSDEM GVYEEETSQG AEEEVPLDPS SSIVEGRYYR
AKGLKENSKF REAIEALEGV ATSSEPLWAF RALKQIAKCW NFKGAQASEG YQDGVRTALV
RLLEHGLRWR QKLGAAYVER SLISTLRMLV PANSQNFVFD EAHEICLPTI EFHLRLLDAV
APLPGDFKDL CTLHMQLRLE NLIWRERLRG ADCTAILSEA PAPQLTAETL LLLLQCHICR
FLRLCQPPAQ QFAELVSELQ DRAERSLALA QQPHAMVLLA FAQCMRGMQQ QPQPHSALRT
HFSACLQGLE EIGSNSSFFR DLNLCGFVLA DALAYSAGRC SHRVDPFALE QIRILRETPI
VHNLQLLYES YVALDLPSFA RALDLLAPFR SALAPLFARL CALARERKLW DAIAPLHSCI
ALADIQRLLC IGSSSLSRDS LLTLMMQGVM ASSARVPFRL DLTRDYVYFG DEPRVQLRAP
AARPGLRHCA HDLGLTSACA RPFQGSSALQ LMDCLSEHRN RAASAAADPA DAVCRARQPL
AAYRTLAALI LDE
