ID   CSN10_CANGA             Reviewed;         643 AA.
AC   Q6FVG5;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=COP9 signalosome complex subunit 10;
GN   Name=RRI2; Synonyms=CSN10; OrderedLocusNames=CAGL0E02057g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the COP9 signalosome (CSN) complex that acts as
CC       an regulator of the ubiquitin (Ubl) conjugation pathway by mediating
CC       the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-
CC       protein ligase complexes. The CSN complex is involved in the regulation
CC       of the mating pheromone response (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of a COP9 signalosome-like (CSN) complex.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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DR   EMBL; CR380951; CAG58698.1; -; Genomic_DNA.
DR   RefSeq; XP_445779.1; XM_445779.1.
DR   AlphaFoldDB; Q6FVG5; -.
DR   STRING; 5478.XP_445779.1; -.
DR   EnsemblFungi; CAG58698; CAG58698; CAGL0E02057g.
DR   GeneID; 2887398; -.
DR   KEGG; cgr:CAGL0E02057g; -.
DR   CGD; CAL0128748; CAGL0E02057g.
DR   VEuPathDB; FungiDB:CAGL0E02057g; -.
DR   eggNOG; ENOG502RXR9; Eukaryota.
DR   HOGENOM; CLU_031729_0_0_1; -.
DR   InParanoid; Q6FVG5; -.
DR   OMA; DFMMSDD; -.
DR   Proteomes; UP000002428; Chromosome E.
DR   GO; GO:0008180; C:COP9 signalosome; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000717; PCI_dom.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..643
FT                   /note="COP9 signalosome complex subunit 10"
FT                   /id="PRO_0000121022"
FT   DOMAIN          331..517
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          573..594
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..32
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   643 AA;  74582 MW;  3D3E2AB2B7FEBB20 CRC64;
     MTDESDNYND FMMSDEDMDS IEMEDEENDV EGDEGQRGGQ EWVQNYEQGL SLWNDENYVA
     ARQVFLKTLS MLVSEEELIE MRCKIHRQVL ECWCKILMYG EPDNEQSTEI IADFRNFVEL
     VNELHGKANC SLDLSSMFHH VTMDFMPNIY DRTFIPGITD DEESSKWAKM TFKTTILQIL
     QGSWVCHTFP EVGLLLQQEL HVLQAWIKTF DKERDLYAIS ESLRKDINTL NELQLILQCY
     IARYIEDQHL LCNEGEVFRM CLNQLDQKCN ESLAVAQRSD INLILHFSKA LFLILFELDQ
     DDLGDGNKVT GSTCVRRFVT IHKFYQNIEC CKEEFWECLK NLEELGTNKF RFERFMQIIV
     GGFVLCAMIM HRGSQTRLAG TSGNADINPF DYEQLRIAPD HIFVDKLRRI YDVFVGLQIQ
     EMHSCLIELE CIRAPLSRLF DQVCYLIQKR KLFSEIAPIY SCISIQDLRQ KLQIDPSVPP
     TRDEILVHLM RYCMQDRGIN FKLDLVADTV TFYSEQHSEP LHDAVFSETR MGHKSHKSSI
     SKDRAIVEDI KAAHEMPEVE YAHDIGILES QVDSQSHSKS NTKSMSRHVS GHDPDSFGQD
     TISFFDTLRL ARETYQGSNI DNSVYTIAKL TNEALQEISN DVR