ID   CSN10_KLULA             Reviewed;         583 AA.
AC   Q6CXL5;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=COP9 signalosome complex subunit 10;
GN   Name=RRI2; Synonyms=CSN10; OrderedLocusNames=KLLA0A07293g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the COP9 signalosome (CSN) complex that acts as
CC       an regulator of the ubiquitin (Ubl) conjugation pathway by mediating
CC       the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-
CC       protein ligase complexes. The CSN complex is involved in the regulation
CC       of the mating pheromone response (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of a COP9 signalosome-like (CSN) complex.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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DR   EMBL; CR382121; CAH02912.1; -; Genomic_DNA.
DR   RefSeq; XP_451324.1; XM_451324.1.
DR   AlphaFoldDB; Q6CXL5; -.
DR   STRING; 28985.XP_451324.1; -.
DR   EnsemblFungi; CAH02912; CAH02912; KLLA0_A07293g.
DR   GeneID; 2896316; -.
DR   KEGG; kla:KLLA0_A07293g; -.
DR   eggNOG; ENOG502RXR9; Eukaryota.
DR   HOGENOM; CLU_031729_0_0_1; -.
DR   InParanoid; Q6CXL5; -.
DR   Proteomes; UP000000598; Chromosome A.
DR   GO; GO:0008180; C:COP9 signalosome; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000717; PCI_dom.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..583
FT                   /note="COP9 signalosome complex subunit 10"
FT                   /id="PRO_0000121023"
FT   DOMAIN          297..485
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          1..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..34
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   583 AA;  67680 MW;  7C7C77CA66EC206D CRC64;
     MSDEEDYAEY MMSEEDMSSF EMDVDSDVEP DDAGLEQDQQ VTGDDYDGSA GNSGDSMAAV
     EKQCESWYDT GKAFKNDDQF EEARKWFMKC HASPIWWFKS LKQIIKSDLS QGLRVNERLR
     EMFELVSTKK EMIGEESYIY GSVKRLINRI VPDLNSHLLF TERLRQSSID VSTLMERQRY
     LDILEKSVAD MDQELRDLVT IRKIVYCVWI HVLRWEQIPK ETLEDLHENV NLETYFILLQ
     LHVRTFVDED IVHLIELVKV VDEMGRFMTN SLSVSQIPTV TSVYHFARFL TLWKSTDHYN
     QSQMLSKCEG ELTSCFQDLE AIGGTERDGL MLTRFSLMGI VFCHLLLNDK TKLVPFELEQ
     IKVLEADELV VLLQELYQCW LDMDIYALEQ CLLQLEDFYS PWYNVMIEKI IALCQSNKLW
     KRIAPTYSCI ALQDLMAKLE TGNTITMNRD QLLTLLMKSI AKDTADVYYK LDLVEDYVYF
     GEEYFVPLRS EELNIVNPLS QQMGSEIIGK DEWLCNVSNW HKPKVPKKLS AIEFMDYMKA
     ARVTISQTNL AHHEPTVTSF LLKLSTITHA QLTQNSSSLA STN