ID   CSN11_ASHGO             Reviewed;         420 AA.
AC   Q75CD6;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=COP9 signalosome complex subunit 11;
GN   Name=PCI8; Synonyms=CSN11; OrderedLocusNames=ACL027C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Component of the COP9 signalosome (CSN) complex that acts as
CC       an regulator of the ubiquitin (Ubl) conjugation pathway by mediating
CC       the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-
CC       protein ligase complexes The CSN complex is involved in the regulation
CC       of the mating pheromone response. PCI8 may also be involved in
CC       transcriptional and translational control (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of a COP9 signalosome-like (CSN) complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
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DR   EMBL; AE016816; AAS51201.1; -; Genomic_DNA.
DR   RefSeq; NP_983377.1; NM_208730.1.
DR   AlphaFoldDB; Q75CD6; -.
DR   STRING; 33169.AAS51201; -.
DR   EnsemblFungi; AAS51201; AAS51201; AGOS_ACL027C.
DR   GeneID; 4619502; -.
DR   KEGG; ago:AGOS_ACL027C; -.
DR   eggNOG; ENOG502RK42; Eukaryota.
DR   HOGENOM; CLU_051217_0_0_1; -.
DR   InParanoid; Q75CD6; -.
DR   OMA; NEICETS; -.
DR   Proteomes; UP000000591; Chromosome III.
DR   GO; GO:0008180; C:COP9 signalosome; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000717; PCI_dom.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..420
FT                   /note="COP9 signalosome complex subunit 11"
FT                   /id="PRO_0000121025"
FT   DOMAIN          177..346
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          386..420
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        400..420
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   420 AA;  48143 MW;  A4F5E56FF808D796 CRC64;
     MDQFEVLVAV ERLFFAWEQI SDKETLVERL EGRLADMNLS LSTSPHRSLF LPYLGTRKDH
     NVADPDTISS EYGLQLLVLE NALAHNYSKA ISLLESSTVG DVGYIEWCRC MMRLNILGKS
     YGNNSELDIG LRSYLRNGAQ GSSLLLTDEV SDCRMLGFAS LFLQEEYFIA VHHMVRSIHE
     HPSLVDYLLR EEDGRDIFIL KEEYKLMLTI AVLVAIPLEN YQDFLLLEDL NPLLQGLPEL
     HVCLNLLVST SFGSFFARWL GPIQELANRS CFLAPVWHSV NSHMRSKILV FYIKISERVT
     VSYLARTLDI PYDTVMADVS SLIQKFDINI GIEGDLVYYK EDLPVGNLVS KVSQIQREID
     SKLLVMKQKN DALRSFIENM LKEQSVEPLN RSQDMDAFEL HEQSEDEEYE EEHLEEGENV