ID   CSN11_CANGA             Reviewed;         452 AA.
AC   Q6FIP7;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=COP9 signalosome complex subunit 11;
GN   Name=PCI8; Synonyms=CSN11; OrderedLocusNames=CAGL0M12749g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the COP9 signalosome (CSN) complex that acts as
CC       an regulator of the ubiquitin (Ubl) conjugation pathway by mediating
CC       the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-
CC       protein ligase complexes The CSN complex is involved in the regulation
CC       of the mating pheromone response. PCI8 may also be involved in
CC       transcriptional and translational control (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of a COP9 signalosome-like (CSN) complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
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DR   EMBL; CR380959; CAG62877.1; -; Genomic_DNA.
DR   RefSeq; XP_449897.1; XM_449897.1.
DR   AlphaFoldDB; Q6FIP7; -.
DR   STRING; 5478.XP_449897.1; -.
DR   PRIDE; Q6FIP7; -.
DR   EnsemblFungi; CAG62877; CAG62877; CAGL0M12749g.
DR   GeneID; 2891448; -.
DR   KEGG; cgr:CAGL0M12749g; -.
DR   CGD; CAL0136823; CAGL0M12749g.
DR   VEuPathDB; FungiDB:CAGL0M12749g; -.
DR   eggNOG; ENOG502RK42; Eukaryota.
DR   HOGENOM; CLU_051217_0_0_1; -.
DR   InParanoid; Q6FIP7; -.
DR   OMA; NEICETS; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0008180; C:COP9 signalosome; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000717; PCI_dom.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..452
FT                   /note="COP9 signalosome complex subunit 11"
FT                   /id="PRO_0000121026"
FT   DOMAIN          205..374
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   452 AA;  52360 MW;  C0D6EEB682884958 CRC64;
     MLSQLRQYHP VIELETVAHL LKSEYGDEQE RAQLGQLGLQ IVNRYDGYEC PYKALFEAAV
     SDSKATISHA AGLHYSSAND ESHTNDTDNE HRDDNVMKHL LSGKYLEALA LLDANSKMDK
     SPFKHMEQFA KIMIFSRNYE NVQELELRLQ YSLSDDRIDQ ISKDQQPSQN LSDEKESICR
     IKLYICTSYF IEGRYFECSS KFYKFYIEDP KTMMKILTSK VDGDALLLLP ELKTMIAAST
     LVSIPMNSYD ELISIDELTE LFDTVDILSR SLKLLINTSF KCFLALWNNE FQKTLSRCYL
     LNKSWETAER LMKMKIYCFY LKLSKTLTIS YLSEKLGIEY DEVKESVERL ICSANLYFHL
     DGDVISYSKR SIVDSTVRTL DENCRHINEL LDKQRVRNDK LKEMISGNLL EEEQTIRKSD
     TAKTSNNQEI MDIDDVQFLS DDLEQVDSCI SD