ID   CSN11_KLULA             Reviewed;         389 AA.
AC   Q6CU48;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=COP9 signalosome complex subunit 11;
GN   Name=PCI8; Synonyms=CSN11; OrderedLocusNames=KLLA0C07667g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the COP9 signalosome (CSN) complex that acts as
CC       an regulator of the ubiquitin (Ubl) conjugation pathway by mediating
CC       the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-
CC       protein ligase complexes The CSN complex is involved in the regulation
CC       of the mating pheromone response. PCI8 may also be involved in
CC       transcriptional and translational control (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of a COP9 signalosome-like (CSN) complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
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DR   EMBL; CR382123; CAH01392.1; -; Genomic_DNA.
DR   RefSeq; XP_452541.1; XM_452541.1.
DR   AlphaFoldDB; Q6CU48; -.
DR   STRING; 28985.XP_452541.1; -.
DR   PRIDE; Q6CU48; -.
DR   EnsemblFungi; CAH01392; CAH01392; KLLA0_C07667g.
DR   GeneID; 2892139; -.
DR   KEGG; kla:KLLA0_C07667g; -.
DR   eggNOG; ENOG502RK42; Eukaryota.
DR   HOGENOM; CLU_051217_0_0_1; -.
DR   InParanoid; Q6CU48; -.
DR   OMA; NEICETS; -.
DR   Proteomes; UP000000598; Chromosome C.
DR   GO; GO:0008180; C:COP9 signalosome; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IEA:UniProt.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProt.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..389
FT                   /note="COP9 signalosome complex subunit 11"
FT                   /id="PRO_0000121027"
FT   DOMAIN          143..312
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   389 AA;  46145 MW;  6D1B13D3F8645F86 CRC64;
     MTQGRLFYPL AVLQDRHFRS KYPNYNESRE LKTWSVVSKR FPAWEQKLVS MLLDNKYAES
     IIFINSDVSM SSVGVFKRTK LLIRTHILNS HYKAVIDFES RLNTQPITSE PTELADFIEC
     KLLLILNWFL RGEYHQCLQR FIQLIIDIPN LVELMVTLPK DDIFISNETM FYIITVSALV
     SIPLDNLDTF IHLEELEQFH KHFDVLAGKG KLIINSKFMK FFDWWHNDME RLCKQDYFLE
     KKWDIISKTM RQKMYAFYLR IATKIQISYL SERVGISREI VTQEITQLIS EACLNFQIHD
     DLILYQKFDP QMALNDLMMT EDITLDNKLS QLRRQNHNLR VIVDEHLALR KSRIQRRSKA
     SDEEPMNEEE VFALSENELC NETADTFND