ID   CSN11_YEAST             Reviewed;         444 AA.
AC   P40512; D6VVL3;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 144.
DE   RecName: Full=Cop9 signalosome complex subunit 11;
DE   AltName: Full=Proteasome-COP9 signalosome-eIF3 domain protein 8;
GN   Name=PCI8; Synonyms=CSN11, YIH1; OrderedLocusNames=YIL071C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169870;
RA   Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D.,
RA   Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E.,
RA   Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C.,
RA   Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V.,
RA   Walsh S.V., Whitehead S., Barrell B.G.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.";
RL   Nature 387:84-87(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   DOMAIN.
RX   PubMed=9605331; DOI=10.1002/pro.5560070521;
RA   Aravind L., Ponting C.P.;
RT   "Homologues of 26S proteasome subunits are regulators of transcription and
RT   translation.";
RL   Protein Sci. 7:1250-1254(1998).
RN   [4]
RP   FUNCTION, AND INTERACTION WITH PRT1 AND RPG1.
RX   PubMed=11457827; DOI=10.1074/jbc.m102161200;
RA   Shalev A., Valasek L., Pise-Masison C.A., Radonovich M., Phan L.,
RA   Clayton J., He H., Brady J.N., Hinnebusch A.G., Asano K.;
RT   "Saccharomyces cerevisiae protein Pci8p and human protein eIF3e/Int-6
RT   interact with the eIF3 core complex by binding to cognate eIF3b subunits.";
RL   J. Biol. Chem. 276:34948-34957(2001).
RN   [5]
RP   FUNCTION OF THE COP9 SIGNALOSOME COMPLEX.
RX   PubMed=12186635; DOI=10.1186/1471-2156-3-15;
RA   Wee S., Hetfeld B., Dubiel W., Wolf D.A.;
RT   "Conservation of the COP9/signalosome in budding yeast.";
RL   BMC Genet. 3:15-15(2002).
RN   [6]
RP   FUNCTION OF THE COP9 SIGNALOSOME COMPLEX.
RX   PubMed=12446563; DOI=10.1093/embo-reports/kvf235;
RA   Maytal-Kivity V., Piran R., Pick E., Hofmann K., Glickman M.H.;
RT   "COP9 signalosome components play a role in the mating pheromone response
RT   of S. cerevisiae.";
RL   EMBO Rep. 3:1215-1221(2002).
RN   [7]
RP   INTERACTION WITH RRI1/CSN5, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=11805826; DOI=10.1038/415141a;
RA   Gavin A.-C., Boesche M., Krause R., Grandi P., Marzioch M., Bauer A.,
RA   Schultz J., Rick J.M., Michon A.-M., Cruciat C.-M., Remor M., Hoefert C.,
RA   Schelder M., Brajenovic M., Ruffner H., Merino A., Klein K., Hudak M.,
RA   Dickson D., Rudi T., Gnau V., Bauch A., Bastuck S., Huhse B., Leutwein C.,
RA   Heurtier M.-A., Copley R.R., Edelmann A., Querfurth E., Rybin V.,
RA   Drewes G., Raida M., Bouwmeester T., Bork P., Seraphin B., Kuster B.,
RA   Neubauer G., Superti-Furga G.;
RT   "Functional organization of the yeast proteome by systematic analysis of
RT   protein complexes.";
RL   Nature 415:141-147(2002).
RN   [8]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [9]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
CC   -!- FUNCTION: Component of the COP9 signalosome (CSN) complex that acts as
CC       an regulator of the ubiquitin (Ubl) conjugation pathway by mediating
CC       the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-
CC       protein ligase complexes The CSN complex is involved in the regulation
CC       of the mating pheromone response. PCI8 may also be involved in
CC       transcriptional and translational control.
CC       {ECO:0000269|PubMed:11457827, ECO:0000269|PubMed:12186635,
CC       ECO:0000269|PubMed:12446563}.
CC   -!- SUBUNIT: Component of a COP9 signalosome-like (CSN) complex, composed
CC       of RRI1/CSN5, CSN9, RRI2/CSN10, PCI8/CSN11, CSN12 and CSI1. Interacts
CC       with PRT1 and RPG1, 2 subunits of the core complex of translation
CC       initiation factor 3 (eIF3). {ECO:0000269|PubMed:11457827,
CC       ECO:0000269|PubMed:11805826}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:14562095}. Nucleus
CC       {ECO:0000305|PubMed:14562095}.
CC   -!- MISCELLANEOUS: Present with 504 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
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DR   EMBL; Z38060; CAA86152.1; -; Genomic_DNA.
DR   EMBL; BK006942; DAA08479.1; -; Genomic_DNA.
DR   PIR; S48408; S48408.
DR   RefSeq; NP_085069.3; NM_001179421.3.
DR   AlphaFoldDB; P40512; -.
DR   BioGRID; 34921; 91.
DR   ComplexPortal; CPX-1894; COP9 signalosome complex.
DR   DIP; DIP-4213N; -.
DR   IntAct; P40512; 8.
DR   MINT; P40512; -.
DR   STRING; 4932.YIL071C; -.
DR   MaxQB; P40512; -.
DR   PaxDb; P40512; -.
DR   PRIDE; P40512; -.
DR   EnsemblFungi; YIL071C_mRNA; YIL071C; YIL071C.
DR   GeneID; 854739; -.
DR   KEGG; sce:YIL071C; -.
DR   SGD; S000001333; PCI8.
DR   VEuPathDB; FungiDB:YIL071C; -.
DR   eggNOG; ENOG502RK42; Eukaryota.
DR   GeneTree; ENSGT00510000046608; -.
DR   HOGENOM; CLU_051217_0_0_1; -.
DR   InParanoid; P40512; -.
DR   OMA; NEICETS; -.
DR   BioCyc; YEAST:G3O-31338-MON; -.
DR   PRO; PR:P40512; -.
DR   Proteomes; UP000002311; Chromosome IX.
DR   RNAct; P40512; protein.
DR   GO; GO:0008180; C:COP9 signalosome; IDA:SGD.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IC:ComplexPortal.
DR   GO; GO:0000754; P:adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion; IC:ComplexPortal.
DR   GO; GO:0000338; P:protein deneddylation; IMP:SGD.
DR   InterPro; IPR000717; PCI_dom.
DR   SMART; SM00088; PINT; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..444
FT                   /note="Cop9 signalosome complex subunit 11"
FT                   /id="PRO_0000121028"
FT   DOMAIN          195..367
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          419..439
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   444 AA;  51288 MW;  60C3FCD0237CFEB0 CRC64;
     MFHGAKGPLL IERIGHLLSI NYGEKEERKR WAMQGISYLQ EVQCTSTPYL EILVEESGLR
     PVSLLNSQLV GKPHFSLLGG FDENIARDII SHNFQNAIFQ MESEEVPLTK RYQHLEKITQ
     ISLLCKNFKG IEEIEYNVKN IIQGRKNFDM LNSMEKDRIS HEVVQDDSFS LLRIQMLLCV
     SYFLQERYFD CCTKFFTMMT SEPLTLKVLS EHLDCMNFIS KEEFIMMVNI SVLISIPLDN
     YDDFIYLSDL KQFFQMTPLL VNCLELLINT NFNKFFKIWH GEINKICMES LFLEPSWSSS
     AAVIMRCKIY FFYLRISKKL QFSYLSSTLG IDLEDIKEEL TKLIISGQLN FEIDGDVIHF
     EDSSILQSIV NEISRNGTMI NEVIDKLKNE NTDLKDIIQG NPLMYSGGNN TATIINNESS
     DDMDIDEVND RSDISDSEGG LFEC