ID   CSN12_ASHGO             Reviewed;         412 AA.
AC   Q75BU2;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=COP9 signalosome complex subunit 12;
GN   Name=CSN12; OrderedLocusNames=ACR179C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO 273-274; 284-286; 290-296 AND
RP   318-326.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Component of the COP9 signalosome (CSN) complex that acts as
CC       an regulator of the ubiquitin (Ubl) conjugation pathway by mediating
CC       the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-
CC       protein ligase complexes. The CSN complex is involved in the regulation
CC       of the mating pheromone response (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of a COP9 signalosome-like (CSN) complex.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSN12 family. {ECO:0000305}.
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DR   EMBL; AE016816; AAS51405.2; -; Genomic_DNA.
DR   RefSeq; NP_983581.2; NM_208934.2.
DR   AlphaFoldDB; Q75BU2; -.
DR   SMR; Q75BU2; -.
DR   STRING; 33169.AAS51405; -.
DR   EnsemblFungi; AAS51405; AAS51405; AGOS_ACR179C.
DR   GeneID; 4619713; -.
DR   KEGG; ago:AGOS_ACR179C; -.
DR   eggNOG; KOG2688; Eukaryota.
DR   HOGENOM; CLU_031567_2_1_1; -.
DR   InParanoid; Q75BU2; -.
DR   OMA; TYLIPCH; -.
DR   Proteomes; UP000000591; Chromosome III.
DR   GO; GO:0008180; C:COP9 signalosome; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000791; C:euchromatin; IEA:EnsemblFungi.
DR   GO; GO:0070390; C:transcription export complex 2; IBA:GO_Central.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0000754; P:adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion; IEA:EnsemblFungi.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:EnsemblFungi.
DR   GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR   GO; GO:0000973; P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery; IBA:GO_Central.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR045114; Csn12-like.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR12732; PTHR12732; 1.
DR   Pfam; PF01399; PCI; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..412
FT                   /note="COP9 signalosome complex subunit 12"
FT                   /id="PRO_0000121036"
FT   DOMAIN          220..401
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   412 AA;  46366 MW;  92964A32E41643CC CRC64;
     MIQAVTSCFQ FKRCTTHLLE FIAADKPMVG DALADPSDEK LAHFVRTTAA LKIEYRCAQG
     PSPRVFELAL AQLRALNRIA EWESGWVVYP LYTCARQLVQ MAAALDARTE RAAEAAQCGD
     LATEDHLTQC GRAVHMSLNL CLKDRDPAAS NKRHGAYYFA LLLFRTYARL GAHSLVTNMV
     KVLESRAQDL PPVERAFGER RALTVTYCYY LGRYHACRRA DYEKGFRWLN TALLTCHRDH
     TRHHQLILTY LVPVAFLARR WYPKHHVIAA WPPPQDPAAI HYAALVAALR SGDLGLYDRE
     LVRMQLPLLR RGLYLPLSHL RPYILLRLVK AVWRLSGGSS QLPIRIIAAA LAYSTSATPD
     AGGERLLDHT ECLLANLIAR GYVKGYLSHG NRVLVVSRTE PFPRLVRSET AA