ID   CSN12_ASPFU             Reviewed;         455 AA.
AC   Q4WJX0;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Protein CSN12 homolog;
GN   Name=csn12; ORFNames=AFUA_1G04520;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSN12 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAHF01000007; EAL88162.1; -; Genomic_DNA.
DR   RefSeq; XP_750200.1; XM_745107.2.
DR   AlphaFoldDB; Q4WJX0; -.
DR   SMR; Q4WJX0; -.
DR   STRING; 746128.CADAFUBP00000480; -.
DR   EnsemblFungi; EAL88162; EAL88162; AFUA_1G04520.
DR   GeneID; 3507302; -.
DR   KEGG; afm:AFUA_1G04520; -.
DR   VEuPathDB; FungiDB:Afu1g04520; -.
DR   eggNOG; KOG2688; Eukaryota.
DR   HOGENOM; CLU_031567_1_0_1; -.
DR   InParanoid; Q4WJX0; -.
DR   OMA; TYLIPCH; -.
DR   OrthoDB; 706700at2759; -.
DR   Proteomes; UP000002530; Chromosome 1.
DR   GO; GO:0008180; C:COP9 signalosome; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070390; C:transcription export complex 2; IBA:GO_Central.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR   GO; GO:0000973; P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery; IBA:GO_Central.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR045114; Csn12-like.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR12732; PTHR12732; 1.
DR   Pfam; PF01399; PCI; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..455
FT                   /note="Protein CSN12 homolog"
FT                   /id="PRO_0000121037"
FT   DOMAIN          248..448
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   455 AA;  51244 MW;  E181F1DAE3472295 CRC64;
     MASVFTDFKE GQQNGSGPRL AAALTPIATS QSPDRLLSFY NFSDSDHISA DLRYSLFQAN
     GVKLPKQEQN GWVDIFAAYW KAVGEIVKFE EYNPSASWAK VFDAWKNVAN TLIRGYTNFG
     LQAWTVPCLY VVGKYLRVFA IKADTEISSK GAMAFGDQLQ DDVAADFEKS AKLEEAARII
     NRMFTLCLSD RAPIEESRKW GIYNTTNLLF KTYFKLNSVG LSKNLLRALS ASSADLPELE
     AFPKSHIVTF KYYVGVIHFL DENYREAEEH LAYAWNMCHK GAFKNRELIL TYLVPCHLVT
     THTLPSQKLL APFPRLEKLF RPLCDCIRKG DLVGFDTAMF AGEEEFVKRR IYLPLERGRD
     IALRNLFRKV FIAGGFEESK DGQPPIRRTR VPVAEFAAAL RIGTHADDRS RVDIDEVECL
     LSNLIYKGLM KGYIARERGM VVLSKGGTAF PGTGV