ID   CSN12_CANGA             Reviewed;         449 AA.
AC   Q6FJ48;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=COP9 signalosome complex subunit 12;
GN   Name=CSN12; OrderedLocusNames=CAGL0M09251g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the COP9 signalosome (CSN) complex that acts as
CC       an regulator of the ubiquitin (Ubl) conjugation pathway by mediating
CC       the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-
CC       protein ligase complexes. The CSN complex is involved in the regulation
CC       of the mating pheromone response (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of a COP9 signalosome-like (CSN) complex.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSN12 family. {ECO:0000305}.
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DR   EMBL; CR380959; CAG62724.1; -; Genomic_DNA.
DR   RefSeq; XP_449746.1; XM_449746.1.
DR   AlphaFoldDB; Q6FJ48; -.
DR   SMR; Q6FJ48; -.
DR   STRING; 5478.XP_449746.1; -.
DR   EnsemblFungi; CAG62724; CAG62724; CAGL0M09251g.
DR   GeneID; 2891310; -.
DR   KEGG; cgr:CAGL0M09251g; -.
DR   CGD; CAL0136487; CAGL0M09251g.
DR   VEuPathDB; FungiDB:CAGL0M09251g; -.
DR   eggNOG; KOG2688; Eukaryota.
DR   HOGENOM; CLU_031567_2_1_1; -.
DR   InParanoid; Q6FJ48; -.
DR   OMA; GEYYGCY; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0008180; C:COP9 signalosome; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR045114; Csn12-like.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR12732; PTHR12732; 1.
DR   Pfam; PF01399; PCI; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..449
FT                   /note="COP9 signalosome complex subunit 12"
FT                   /id="PRO_0000121038"
FT   DOMAIN          233..444
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   449 AA;  52648 MW;  50065C165F8673FD CRC64;
     MEYSRFVDCF ERRSYTAEFL EFVGFKLSSE PLGATALILG GSQAKQARYG DVNALYDAIV
     QIKLKESLTS LRELDPNAAV KKNKQRKVHQ RVVDVFQALT NELRILNKIL ERSDDSVWLV
     YPVYTVCHDV STFLRDTGKY MQLESRKQLW EECIRVIHRS FMICLNDKNP NMQENKRGGC
     ILFANLEMMF YKMLRNRDMM KNLIKVLEST GMTDISRQRD NKVLKRHRSQ KIIFNYFIGE
     YYGCYLFQFN KAQEHLQVCV SEFPVKYTSS KWFKRIIHLY TQFRMLATSN KLIHVELPRE
     TNEKFANAYD SDLMNKCYKN GDTIVFDELI KEHAAQYLID GTYSAMLLIK ELVFLRLVKV
     CYKVNDKKSI LPLDLIAAGY RIHFRNHDNE ENRVTTTNPR KLQKKNEDLL DELECRIANL
     IANGRIKGYL SHSQRCMVLS KTEPFPLAS