ID   CSN12_KLULA             Reviewed;         424 AA.
AC   Q6CPB1;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=COP9 signalosome complex subunit 12;
GN   Name=CSN12; OrderedLocusNames=KLLA0E06193g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the COP9 signalosome (CSN) complex that acts as
CC       an regulator of the ubiquitin (Ubl) conjugation pathway by mediating
CC       the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-
CC       protein ligase complexes. The CSN complex is involved in the regulation
CC       of the mating pheromone response.
CC   -!- SUBUNIT: Component of a COP9 signalosome-like (CSN) complex.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSN12 family. {ECO:0000305}.
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DR   EMBL; CR382125; CAG99315.1; -; Genomic_DNA.
DR   RefSeq; XP_454228.1; XM_454228.1.
DR   AlphaFoldDB; Q6CPB1; -.
DR   SMR; Q6CPB1; -.
DR   STRING; 28985.XP_454228.1; -.
DR   EnsemblFungi; CAG99315; CAG99315; KLLA0_E06227g.
DR   GeneID; 2894104; -.
DR   KEGG; kla:KLLA0_E06227g; -.
DR   eggNOG; KOG2688; Eukaryota.
DR   HOGENOM; CLU_031567_2_1_1; -.
DR   InParanoid; Q6CPB1; -.
DR   OMA; TYLIPCH; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0008180; C:COP9 signalosome; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR045114; Csn12-like.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR12732; PTHR12732; 1.
DR   Pfam; PF01399; PCI; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..424
FT                   /note="COP9 signalosome complex subunit 12"
FT                   /id="PRO_0000121042"
FT   DOMAIN          224..415
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   424 AA;  49736 MW;  346C1C51FAF1FAFC CRC64;
     MAQLVYLCFR DNTLSEPFSN LIDMKYDHQI KVSKPSFKLP EFEKVKQLIE ICNELKRTYK
     KEPNGGSPQL FHLALEQLRV LNRIYENRTN WMTELLYQSG EQLYAIANKL DEIQNKLDGP
     EDTGDGDEEE SYLIQAGRVM HMTLNICFKD RNERVDENRK IGVFYIGTLL FKLYNRIKAY
     GLLNNMCKVF ESHFNEIGPY LSRINNDLIV IRFKFYMGLY YGYEKNNYAL GFKWLQETFD
     ICTLYESIPS TYKVRSQVLI YLIPMRILHL RHYPRLAPLR RTYPSVAKIY TMLVKSLCTG
     NLKLYEKFIE DNEFYLVKRN LYVTVLKMKE LVELKLVKKA WILNGGNTKV PLDMLAKAFQ
     ISRGTPCHVT ENVAPNHDQE LDELECILAT LISKNYIKGY LSHSHRVMMT SKTPFPGLAK
     PLER