ID   CSN12_NEUCR             Reviewed;         452 AA.
AC   Q7SD63; V5IQ30;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-FEB-2014, sequence version 2.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Protein CSN12 homolog;
DE   AltName: Full=COP9 signalosome protein 8;
GN   Name=csn-8; Synonyms=csn12; ORFNames=NCU08388;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- SIMILARITY: Belongs to the CSN12 family. {ECO:0000305}.
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DR   EMBL; CM002236; ESA44132.1; -; Genomic_DNA.
DR   EMBL; CM002236; ESA44133.1; -; Genomic_DNA.
DR   RefSeq; XP_011393203.1; XM_011394901.1.
DR   RefSeq; XP_011393204.1; XM_011394902.1.
DR   AlphaFoldDB; Q7SD63; -.
DR   SMR; Q7SD63; -.
DR   STRING; 5141.EFNCRP00000006434; -.
DR   EnsemblFungi; ESA44132; ESA44132; NCU08388.
DR   EnsemblFungi; ESA44133; ESA44133; NCU08388.
DR   GeneID; 3880084; -.
DR   KEGG; ncr:NCU08388; -.
DR   VEuPathDB; FungiDB:NCU08388; -.
DR   HOGENOM; CLU_031567_1_0_1; -.
DR   InParanoid; Q7SD63; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0070390; C:transcription export complex 2; IBA:GO_Central.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR   GO; GO:0000973; P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery; IBA:GO_Central.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR045114; Csn12-like.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR12732; PTHR12732; 1.
DR   Pfam; PF01399; PCI; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..452
FT                   /note="Protein CSN12 homolog"
FT                   /id="PRO_0000121043"
FT   DOMAIN          249..446
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   452 AA;  51563 MW;  287452C70D0A733A CRC64;
     MDSLIRTFSN AQSSRDGYQL AQTLSPDLPQ QQLQAIWKSC GHHDAQNVIK RGIQNSTSGF
     EKLPKDEVQG WSDVYLAYWK AIGELLPALN QAPQSSWTKV YDAWKELLSA LYRGYIGQGF
     EAWSIPCLYV VAKNLRFFAL KADEERNNNV AAGDTSGQIF QDDFDPESEQ NQKLEDCARQ
     LNRIFTLCLN DRAPLEESRK WGIYYIINLL FKTYFKLNSA SLSKNILKTL SAYRGDMPPL
     SAFPKSQQVT FKYYEGVLCF LEENYFQAEE HLTQAWSLCH KDAMKNKELI LTYLVPCHLL
     TTHTLPSQKL LEPYPRLQKL FLPLSNCIKK GELHAFDLAL QQGEDEFVKR RIYLTLERGR
     DIALRNLLRK VFIAGGFEES KVEGGPRVRR TRIPVAEFAA AISLGSKQML ETDEIECLMA
     NMIYKNLMKG YIARERGFVV LSKSGAFPGT GV