CSN1_DICDI
ID CSN1_DICDI Reviewed; 458 AA.
AC Q54QX3; Q2PQ78;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=COP9 signalosome complex subunit 1;
DE Short=Signalosome subunit 1;
GN Name=csn1; ORFNames=DDB_G0283587;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND IDENTIFICATION IN THE CSN COMPLEX.
RX PubMed=16781008; DOI=10.1016/j.ejcb.2006.04.006;
RA Rosel D., Kimmel A.R.;
RT "The COP9 signalosome regulates cell proliferation of Dictyostelium
RT discoideum.";
RL Eur. J. Cell Biol. 85:1023-1034(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Essential component of the COP9 signalosome complex (CSN), a
CC complex involved in various cellular and developmental processes. The
CC CSN complex is an essential regulator of the ubiquitin (Ubl)
CC conjugation pathway by mediating the deneddylation of the cullin
CC subunits of E3 ligase complexes, leading to modify the Ubl ligase
CC activity.
CC -!- SUBUNIT: Component of the CSN complex. The holocomplex is comprised of
CC 8 subunits csn1-8. In the complex, it probably interacts directly with
CC csn2 and csn5. {ECO:0000269|PubMed:16781008}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- DOMAIN: The PCI domain is necessary and sufficient for the interactions
CC with other CSN subunits of the complex. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CSN1 family. {ECO:0000305}.
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DR EMBL; DQ309429; ABC46693.1; -; mRNA.
DR EMBL; AAFI02000055; EAL65671.1; -; Genomic_DNA.
DR RefSeq; XP_639011.1; XM_633919.1.
DR AlphaFoldDB; Q54QX3; -.
DR SMR; Q54QX3; -.
DR STRING; 44689.DDB0233099; -.
DR PaxDb; Q54QX3; -.
DR EnsemblProtists; EAL65671; EAL65671; DDB_G0283587.
DR GeneID; 8624141; -.
DR KEGG; ddi:DDB_G0283587; -.
DR dictyBase; DDB_G0283587; csn1.
DR eggNOG; KOG0686; Eukaryota.
DR HOGENOM; CLU_022348_1_0_1; -.
DR InParanoid; Q54QX3; -.
DR OMA; QNWAHVM; -.
DR PhylomeDB; Q54QX3; -.
DR Reactome; R-DDI-5696394; DNA Damage Recognition in GG-NER.
DR Reactome; R-DDI-6781823; Formation of TC-NER Pre-Incision Complex.
DR Reactome; R-DDI-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR Reactome; R-DDI-8951664; Neddylation.
DR Reactome; R-DDI-9013422; RHOBTB1 GTPase cycle.
DR PRO; PR:Q54QX3; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0008180; C:COP9 signalosome; IPI:dictyBase.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000338; P:protein deneddylation; IEA:InterPro.
DR InterPro; IPR033008; CSN1.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR019585; Rpn7/CSN1.
DR InterPro; IPR045135; Rpn7_N.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR14145; PTHR14145; 1.
DR PANTHER; PTHR14145:SF2; PTHR14145:SF2; 1.
DR Pfam; PF01399; PCI; 1.
DR Pfam; PF10602; RPN7; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50250; PCI; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT CHAIN 1..458
FT /note="COP9 signalosome complex subunit 1"
FT /id="PRO_0000327770"
FT DOMAIN 218..388
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 458 AA; 53067 MW; 6F37E6102F9D7F2C CRC64;
MEDMQVEKNT EGSSSSSSNN NNNNSISNEF DLETYINNYS GFTKIHRLIF IADNCKQLEV
EAYNMALKEV QKTPNLELYN TIINKSHGIL ELDPVYIENL SKKNSLQLDK LEQDLNTAKS
NMVKDSIRFA QNDLGEFYYK IGDHQNALKC FIRTRDYCTT SKHVLAMCFN IIKLGVDTQN
YTHAPSYIAK AEQSPDLDNV SNAKLRSVNG LYNLDGSRYK LAARKFIETP FEQSNVFSDI
ISPQDIAYYG GLCALATFDR NELKKKVIDD PMFKNYLELV PELRELINDF YNTKYGSCLK
YLDKMKPILL LDIHLYKHVE ILYQRIRSKA LVQYFSPYQS VDMNIMASAF NTTVTLLEKE
ISKLIMENEI QARIDSHNKR LYARKADQRT TTFEKTVQVG SDFQNSSNSL LLRLEMLNNN
ISTVSNRKDN ERGNWENPHH HHQMQHQMFG LFNNNNKF
