CSN1_DROME
ID CSN1_DROME Reviewed; 525 AA.
AC Q9VVU5; Q9XYW3;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=COP9 signalosome complex subunit 1b;
DE Short=Dch1-2;
DE Short=Signalosome subunit 1b;
GN Name=CSN1b; ORFNames=CG3889;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE, SUBCELLULAR LOCATION, AND PROBABLE COMPOSITION OF THE
RP CSN COMPLEX.
RX PubMed=10531038; DOI=10.1016/s0960-9822(00)80023-8;
RA Freilich S., Oron E., Kapp Y., Nevo-Caspi Y., Orgad S., Segal D.,
RA Chamovitz D.A.;
RT "The COP9 signalosome is essential for development of Drosophila
RT melanogaster.";
RL Curr. Biol. 9:1187-1190(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP FUNCTION OF CSN COMPLEX.
RX PubMed=12737805; DOI=10.1016/s1534-5807(03)00121-7;
RA Doronkin S., Djagaeva I., Beckendorf S.K.;
RT "The COP9 signalosome promotes degradation of Cyclin E during early
RT Drosophila oogenesis.";
RL Dev. Cell 4:699-710(2003).
CC -!- FUNCTION: Essential component of the COP9 signalosome complex (CSN), a
CC complex involved in various cellular and developmental processes. The
CC CSN complex is an essential regulator of the ubiquitin (Ubl)
CC conjugation pathway by mediating the deneddylation of the cullin
CC subunits of the SCF-type E3 ligase complexes, leading to decrease the
CC Ubl ligase activity of SCF. The CSN complex plays an essential role in
CC oogenesis and embryogenesis and is required for proper photoreceptor R
CC cell differentiation and promote lamina glial cell migration or axon
CC targeting. It also promotes Ubl-dependent degradation of cyclin E
CC (CycE) during early oogenesis. {ECO:0000269|PubMed:12737805}.
CC -!- SUBUNIT: Component of the CSN complex, probably composed of CSN1b,
CC alien/CSN2, CSN3, CSN4, CSN5, CSN6, CSN7 and CSN8.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:10531038}. Nucleus
CC {ECO:0000305|PubMed:10531038}.
CC -!- SIMILARITY: Belongs to the CSN1 family. {ECO:0000305}.
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DR EMBL; AF129080; AAD28605.1; -; mRNA.
DR EMBL; AE014296; AAF49212.1; -; Genomic_DNA.
DR EMBL; AY051972; AAK93396.1; -; mRNA.
DR RefSeq; NP_524152.2; NM_079428.3.
DR AlphaFoldDB; Q9VVU5; -.
DR SMR; Q9VVU5; -.
DR BioGRID; 65343; 1.
DR IntAct; Q9VVU5; 3.
DR STRING; 7227.FBpp0074841; -.
DR PaxDb; Q9VVU5; -.
DR PRIDE; Q9VVU5; -.
DR DNASU; 40063; -.
DR EnsemblMetazoa; FBtr0075074; FBpp0074841; FBgn0027057.
DR GeneID; 40063; -.
DR KEGG; dme:Dmel_CG3889; -.
DR CTD; 40063; -.
DR FlyBase; FBgn0027057; CSN1b.
DR VEuPathDB; VectorBase:FBgn0027057; -.
DR eggNOG; KOG0686; Eukaryota.
DR GeneTree; ENSGT00510000046608; -.
DR HOGENOM; CLU_022348_1_0_1; -.
DR InParanoid; Q9VVU5; -.
DR OMA; QNWAHVM; -.
DR OrthoDB; 859626at2759; -.
DR PhylomeDB; Q9VVU5; -.
DR Reactome; R-DME-5696394; DNA Damage Recognition in GG-NER.
DR Reactome; R-DME-6781823; Formation of TC-NER Pre-Incision Complex.
DR Reactome; R-DME-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR Reactome; R-DME-8951664; Neddylation.
DR Reactome; R-DME-9013422; RHOBTB1 GTPase cycle.
DR BioGRID-ORCS; 40063; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 40063; -.
DR PRO; PR:Q9VVU5; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0027057; Expressed in eye disc (Drosophila) and 29 other tissues.
DR Genevisible; Q9VVU5; DM.
DR GO; GO:0008180; C:COP9 signalosome; ISS:FlyBase.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0036099; P:female germ-line stem cell population maintenance; IMP:FlyBase.
DR GO; GO:0007281; P:germ cell development; IMP:FlyBase.
DR GO; GO:0048142; P:germarium-derived cystoblast division; IMP:FlyBase.
DR GO; GO:0048140; P:male germ-line cyst encapsulation; IMP:FlyBase.
DR GO; GO:0000338; P:protein deneddylation; ISS:FlyBase.
DR GO; GO:0050821; P:protein stabilization; IMP:FlyBase.
DR InterPro; IPR033008; CSN1.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR019585; Rpn7/CSN1.
DR InterPro; IPR045135; Rpn7_N.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR14145; PTHR14145; 1.
DR PANTHER; PTHR14145:SF2; PTHR14145:SF2; 1.
DR Pfam; PF01399; PCI; 1.
DR Pfam; PF10602; RPN7; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50250; PCI; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Developmental protein; Differentiation; Nucleus; Oogenesis;
KW Reference proteome; Signalosome.
FT CHAIN 1..525
FT /note="COP9 signalosome complex subunit 1b"
FT /id="PRO_0000120964"
FT DOMAIN 298..460
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT CONFLICT 48
FT /note="Y -> F (in Ref. 1; AAD28605)"
FT /evidence="ECO:0000305"
FT CONFLICT 222
FT /note="D -> N (in Ref. 1; AAD28605)"
FT /evidence="ECO:0000305"
FT CONFLICT 324
FT /note="L -> F (in Ref. 1; AAD28605)"
FT /evidence="ECO:0000305"
FT CONFLICT 398
FT /note="I -> K (in Ref. 1; AAD28605)"
FT /evidence="ECO:0000305"
FT CONFLICT 522
FT /note="L -> F (in Ref. 1; AAD28605)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 525 AA; 58215 MW; AA55CE3FD66656F2 CRC64;
MPVLPMPPLM QNAVEPMQVD IAPPNEDNEN NEEQQIVVEN PSIDLEVYAN QYAGIVRLHR
LIYVADVCPV LAVEALKMAI TYVQTTYNVN LYQVLHKRLS DLNAGNAPAP PANAGGDQAG
AAAPGPLAAA PLPDIAAQPV AQAQGQAQPA VEKDAFAYDA AWVDTKMKKA ALKLEKLDSD
LKNYKSNSIK ESIRRGHDDL ADHYLSCGDL TNALKCYSRA RDYCTSGKHV VNMCLNVIKV
SIYLQNWAHV MSYISKAEST PDFAEGSKEA NAQVHTRLEC AAGLAELQQK KYKVAAKHFL
NANFDHCDFP EMISTSNVAV YGGLCALATF DRQELKRLVI ASTSFKLFLE LEPQLRDIIF
KFYESKYASC LTLLDEIRDN LLVDMYIAPH VTTLYTKIRN RALIQYFSPY MSADMHKMAM
AFNSSVGDLE NEVMQLILDG QIQARIDSHN KILFAKEADQ RNSTFERALI MGKQYQRHTR
MLVLRAAMLK SHIHVKSISR EGGSNHGAEL CVSAGSSTTA QLARI
