ID   CSN1_EMENI              Reviewed;         498 AA.
AC   Q5BD89; C8VMM0; Q56UN7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=COP9 signalosome complex subunit 1;
DE            Short=CSN complex subunit 1;
GN   Name=csnA; Synonyms=csn1; ORFNames=AN1491;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, IDENTIFICATION IN THE CSN
RP   COMPLEX, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=17470786; DOI=10.1073/pnas.0702108104;
RA   Busch S., Schwier E.U., Nahlik K., Bayram O., Helmstaedt K., Draht O.W.,
RA   Krappmann S., Valerius O., Lipscomb W.N., Braus G.H.;
RT   "An eight-subunit COP9 signalosome with an intact JAMM motif is required
RT   for fungal fruit body formation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8089-8094(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- FUNCTION: Component of the COP9 signalosome (CSN) complex that acts as
CC       an regulator of the ubiquitin (Ubl) conjugation pathway by mediating
CC       the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-
CC       protein ligase complexes (By similarity). The CSN complex seems to link
CC       protein degradation to sexual development. Required for fruit body
CC       formation. {ECO:0000250, ECO:0000269|PubMed:17470786}.
CC   -!- SUBUNIT: Component of the COP9 signalosome (CSN) complex.
CC       {ECO:0000269|PubMed:17470786}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSN1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAA64621.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AY574249; AAT73769.1; -; Genomic_DNA.
DR   EMBL; AACD01000022; EAA64621.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BN001307; CBF84973.1; -; Genomic_DNA.
DR   RefSeq; XP_659095.1; XM_654003.1.
DR   AlphaFoldDB; Q5BD89; -.
DR   SMR; Q5BD89; -.
DR   DIP; DIP-60925N; -.
DR   IntAct; Q5BD89; 3.
DR   STRING; 162425.CADANIAP00008114; -.
DR   EnsemblFungi; CBF84973; CBF84973; ANIA_01491.
DR   EnsemblFungi; EAA64621; EAA64621; AN1491.2.
DR   GeneID; 2874595; -.
DR   KEGG; ani:AN1491.2; -.
DR   VEuPathDB; FungiDB:AN1491; -.
DR   eggNOG; KOG0686; Eukaryota.
DR   HOGENOM; CLU_022348_1_1_1; -.
DR   InParanoid; Q5BD89; -.
DR   OMA; QNWAHVM; -.
DR   OrthoDB; 859626at2759; -.
DR   Proteomes; UP000000560; Chromosome VII.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0008180; C:COP9 signalosome; IDA:AspGD.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070791; P:cleistothecium development; IMP:AspGD.
DR   GO; GO:0000338; P:protein deneddylation; IEA:InterPro.
DR   InterPro; IPR033008; CSN1.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR019585; Rpn7/CSN1.
DR   InterPro; IPR045135; Rpn7_N.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR14145; PTHR14145; 1.
DR   PANTHER; PTHR14145:SF2; PTHR14145:SF2; 1.
DR   Pfam; PF01399; PCI; 1.
DR   Pfam; PF10602; RPN7; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..498
FT                   /note="COP9 signalosome complex subunit 1"
FT                   /id="PRO_0000314738"
FT   DOMAIN          249..430
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   498 AA;  55664 MW;  B7EDC2906BD334FE CRC64;
     MEPMLPEAGE AALLSSYAPQ ASGSMGVDPD PITGLVSTSA APLVRVEEAP KFELESYIAN
     YTGRTRFNRL YLIGTCSSYL AVDALKAAIA EAKSGKDVAR YLRAVQALAD VAPNEPEATI
     DSDWVERSQK VVKAETDRLE HELRGYKNNL IKESIRMGNE ELGQHYHRIG DLTSAFKAYS
     RMRDFCTTPS HIASMLFKII NVAIERGDWL NVQSNVHRLR SQGGKPEEQA KHQPKISAAM
     GLSQLHSGSY LEAANSFIAT DPSLGDTFNE VLTSNDVAVY GGLCALASMD RNELQRRVLD
     NSSFRNFLEL EPHIRRAISF FCNSKFRPCL EILEAYRADY LLDIHLQRHV QVLYNRIRTK
     SIQQYLIPFN RVSLESMAKI FVLGNPTSQS SQSDSKSAFV QELISLIQDG TLDARIDLEK
     HVLVSTQGDK RIEVQEAVLD SLDNYVREAH LRLLRSNIIR AGLEVRPLGE DRRTKLEERG
     KKGHSAIGNL LRATGMKQ