ID   CSN1_NEUCR              Reviewed;         425 AA.
AC   Q7RXQ1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=COP9 signalosome complex subunit 1;
DE            Short=CSN complex subunit 1;
GN   Name=csn-1; ORFNames=NCU00157;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY,
RP   IDENTIFICATION IN THE COP9 SIGNALOSOME COMPLEX, AND FUNCTION OF THE COP9
RP   SIGNALOSOME COMPLEX.
RX   PubMed=15961524; DOI=10.1101/gad.1322205;
RA   He Q., Cheng P., He Q., Liu Y.;
RT   "The COP9 signalosome regulates the Neurospora circadian clock by
RT   controlling the stability of the SCFFWD-1 complex.";
RL   Genes Dev. 19:1518-1531(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Component of the COP9 signalosome (CSN) complex that acts as
CC       an regulator of the ubiquitin (Ubl) conjugation pathway by mediating
CC       the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-
CC       protein ligase complexes (By similarity). The CSN complex is involved
CC       in the regulation of the circadian clock through its control of the
CC       stability of the SCF(FWD-1) complex. {ECO:0000250,
CC       ECO:0000269|PubMed:15961524}.
CC   -!- SUBUNIT: Component of the COP9 signalosome (CSN) complex.
CC       {ECO:0000269|PubMed:15961524}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSN1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAA27434.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; DQ242510; ABB36580.1; -; mRNA.
DR   EMBL; CM002238; EAA27434.2; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_956670.2; XM_951577.2.
DR   AlphaFoldDB; Q7RXQ1; -.
DR   SMR; Q7RXQ1; -.
DR   STRING; 5141.EFNCRP00000000264; -.
DR   EnsemblFungi; EAA27434; EAA27434; NCU00157.
DR   GeneID; 3872817; -.
DR   KEGG; ncr:NCU00157; -.
DR   HOGENOM; CLU_022348_1_1_1; -.
DR   InParanoid; Q7RXQ1; -.
DR   Proteomes; UP000001805; Chromosome 3, Linkage Group III.
DR   GO; GO:0008180; C:COP9 signalosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000338; P:protein deneddylation; IEA:InterPro.
DR   InterPro; IPR033008; CSN1.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR019585; Rpn7/CSN1.
DR   InterPro; IPR045135; Rpn7_N.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR14145; PTHR14145; 1.
DR   PANTHER; PTHR14145:SF2; PTHR14145:SF2; 1.
DR   Pfam; PF01399; PCI; 1.
DR   Pfam; PF10602; RPN7; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..425
FT                   /note="COP9 signalosome complex subunit 1"
FT                   /id="PRO_0000314739"
FT   DOMAIN          219..379
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   425 AA;  47829 MW;  3AA90FF46FCE82F5 CRC64;
     MDDRKLAFFT AIEDQGGVIV KGRTRFERLF HIGRSSVPLC VDALKAAVQE AKAGSDILRY
     QMAVNSLFQA APNEPEALLD KAWMESKEKE NRDTTAHLQA ELQGYKNNLI KESIRMGNED
     LGKHFEAIGD VEAAMDSFWK MRTEVSSTEQ LVDLGKLLVR VAIERRDWKS IGNHLKPLNS
     VNDSDPKAKA LKTYSKIANG IAALGQERYK EAAFCFVEAS SGVPPEIYNQ IASPNDVAIY
     GGLLALATMD RHELQANLLD NDSFREFLQR EPHIRRAITQ FVNGRYAACI EILESYRPDY
     LLDIYLQKHV PKLYADIRTK SIVQYLKPFS CVRLDTMQKA FNGPGPSIED ELFTMIKDGK
     LNARIDAINK SKALQTLENY EKQALDRIRR MNIMAADLEV KGSRKPGGMN DIPFSMTTDD
     TVSLA