ID   CSN1_SCHPO              Reviewed;         422 AA.
AC   O94308; Q9USF8;
DT   16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 130.
DE   RecName: Full=COP9 signalosome complex subunit 1;
DE            Short=CSN complex subunit 1;
DE            Short=SGN1;
GN   Name=csn1; ORFNames=SPBC215.03c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBUNIT, AND SUBCELLULAR LOCATION.
RX   PubMed=11854407; DOI=10.1091/mbc.01-10-0521;
RA   Mundt K.E., Liu C., Carr A.M.;
RT   "Deletion mutants in COP9/signalosome subunits in fission yeast
RT   Schizosaccharomyces pombe display distinct phenotypes.";
RL   Mol. Biol. Cell 13:493-502(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 113-134, AND SUBCELLULAR
RP   LOCATION.
RC   STRAIN=ATCC 38364 / 968;
RX   PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA   Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA   Hiraoka Y.;
RT   "Large-scale screening of intracellular protein localization in living
RT   fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL   Genes Cells 5:169-190(2000).
RN   [4]
RP   FUNCTION.
RX   PubMed=12695334; DOI=10.1101/gad.1090803;
RA   Liu C., Powell K.A., Mundt K., Wu L., Carr A.M., Caspari T.;
RT   "Cop9/signalosome subunits and Pcu4 regulate ribonucleotide reductase by
RT   both checkpoint-dependent and -independent mechanisms.";
RL   Genes Dev. 17:1130-1140(2003).
CC   -!- FUNCTION: Component of the COP9 signalosome (CSN) complex that acts as
CC       an regulator of the ubiquitin (Ubl) conjugation pathway by mediating
CC       the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-
CC       protein ligase complexes (By similarity). Required, indirectly, for
CC       activation of ribonucleotide reductase through the degradation of the
CC       protein spd1, thereby supplying deoxyribonucleotides for DNA
CC       replication and repair. {ECO:0000250, ECO:0000269|PubMed:12695334}.
CC   -!- SUBUNIT: Component of the COP9 signalosome (CSN) complex composed of at
CC       least csn1, csn2, csn4 and csn5 subunits.
CC       {ECO:0000269|PubMed:11854407}.
CC   -!- INTERACTION:
CC       O94308; Q10990: cdt2; NbExp=2; IntAct=EBI-3647868, EBI-3505190;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC   -!- SIMILARITY: Belongs to the CSN1 family. {ECO:0000305}.
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DR   EMBL; AF314169; AAG29548.1; -; Genomic_DNA.
DR   EMBL; CU329671; CAA22117.1; -; Genomic_DNA.
DR   EMBL; AB027783; BAA87087.1; -; Genomic_DNA.
DR   PIR; T39893; T39893.
DR   RefSeq; NP_596680.1; NM_001022603.2.
DR   AlphaFoldDB; O94308; -.
DR   SMR; O94308; -.
DR   BioGRID; 276881; 191.
DR   IntAct; O94308; 2.
DR   STRING; 4896.SPBC215.03c.1; -.
DR   iPTMnet; O94308; -.
DR   MaxQB; O94308; -.
DR   PaxDb; O94308; -.
DR   EnsemblFungi; SPBC215.03c.1; SPBC215.03c.1:pep; SPBC215.03c.
DR   GeneID; 2540352; -.
DR   KEGG; spo:SPBC215.03c; -.
DR   PomBase; SPBC215.03c; csn1.
DR   VEuPathDB; FungiDB:SPBC215.03c; -.
DR   eggNOG; KOG0686; Eukaryota.
DR   HOGENOM; CLU_022348_1_1_1; -.
DR   InParanoid; O94308; -.
DR   OMA; NGRYSSC; -.
DR   PhylomeDB; O94308; -.
DR   Reactome; R-SPO-6781823; Formation of TC-NER Pre-Incision Complex.
DR   PRO; PR:O94308; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0008180; C:COP9 signalosome; ISO:PomBase.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IMP:PomBase.
DR   GO; GO:0000338; P:protein deneddylation; IMP:PomBase.
DR   InterPro; IPR033008; CSN1.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR019585; Rpn7/CSN1.
DR   InterPro; IPR045135; Rpn7_N.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR14145; PTHR14145; 1.
DR   PANTHER; PTHR14145:SF2; PTHR14145:SF2; 1.
DR   Pfam; PF01399; PCI; 1.
DR   Pfam; PF10602; RPN7; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..422
FT                   /note="COP9 signalosome complex subunit 1"
FT                   /id="PRO_0000120967"
FT   DOMAIN          202..369
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   422 AA;  48657 MW;  37E701F90CEDB2C2 CRC64;
     MSLNLLVNQE ELKRYLDEYG VWSKIFRALF VARNSKPLRS FCVHYAIKEL KEKTYNLELY
     QSLFEEFQDC FENEQLDVEW VESVTFHRKQ NLEQLRRELK AYKNNLIRES IRAAQLDLAS
     FFADVGQFDS ALRSYAKVRE YCTNAGQIAH LSLELMRISI WIGNYSHVLA FGSRAKSTVS
     AAMELTSPIY AYCGLANFCL GDYEEALAHF LKVETDTSDG IITKTDISVY ISLCALACWD
     HKRLIQELER NEEFNALSDL DPSLRRCLQA KCNRKYSLLL DTLQQNAQDY SLDMYLAPQL
     TNLFSLIRER SLLDYLIPYS ALPFSKIAVD FHIDENFIEK NLLEIIEAKK LNGKVDSLQK
     RVYIEPSSEP ENFEDIKNIA QTSLLYSKAL YLQTLAAMNT ENTDDEAPVI AQTNITAEDS
     QN