ID   CSN1_XENLA              Reviewed;         487 AA.
AC   Q6NRT5;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=COP9 signalosome complex subunit 1;
DE            Short=Signalosome subunit 1;
GN   Name=csn1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the COP9 signalosome complex (CSN), a
CC       complex involved in various cellular and developmental processes. The
CC       CSN complex is an essential regulator of the ubiquitin (Ubl)
CC       conjugation pathway by mediating the deneddylation of the cullin
CC       subunits of E3 ligase complexes, leading to modify the Ubl ligase
CC       activity (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the CSN complex, probably composed of cops1,
CC       cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
CC       {ECO:0000250|UniProtKB:Q13098}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSN1 family. {ECO:0000305}.
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DR   EMBL; BC070633; AAH70633.1; -; mRNA.
DR   RefSeq; NP_001084802.1; NM_001091333.1.
DR   AlphaFoldDB; Q6NRT5; -.
DR   SMR; Q6NRT5; -.
DR   DNASU; 431842; -.
DR   GeneID; 431842; -.
DR   KEGG; xla:431842; -.
DR   CTD; 431842; -.
DR   Xenbase; XB-GENE-955154; gps1.L.
DR   OMA; QNWAHVM; -.
DR   OrthoDB; 859626at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 431842; Expressed in testis and 19 other tissues.
DR   GO; GO:0008180; C:COP9 signalosome; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000338; P:protein deneddylation; IEA:InterPro.
DR   InterPro; IPR033008; CSN1.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR019585; Rpn7/CSN1.
DR   InterPro; IPR045135; Rpn7_N.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR14145; PTHR14145; 1.
DR   PANTHER; PTHR14145:SF2; PTHR14145:SF2; 1.
DR   Pfam; PF01399; PCI; 1.
DR   Pfam; PF10602; RPN7; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..487
FT                   /note="COP9 signalosome complex subunit 1"
FT                   /id="PRO_0000120962"
FT   DOMAIN          265..427
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          103..123
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          461..487
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        471..487
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   487 AA;  55272 MW;  32E30EF56F8E10B8 CRC64;
     MPLPVQVFNL QSAVEPMQID ADPQDDQQNM PDVNYVVENP TLDLEQYASS YSGLMRIERL
     QFIADRCPQL RVEALKMALS FVQRTFNVDV YEDIHRKLAE ASREVQNAPD AVPEGSMEPP
     ALDTSWVEAT RKKALLKLEK LDTDLKNYKG NSIKESIRRG HDDLGDHYLD CGDLSNALKC
     YSRARDYCTS AKHVINMCLN VIKVSVYLQN WSHVLSYVSK AESTPEIAEQ RGERDSQTQA
     VLTKLKCAAG LAELAARKYK QAAKCFLLAS FDHCDFPELL SPSNVAVYGG LCALATFDRQ
     ELQRNVISSS SFKLFLELEP QVRDIIFKFY ESKYASCLKM LDEIKDNLLL DMYLAPHVRT
     LYTQIRNRAL IQYFSPYVSA DMYKMATAFN TTVSALEDEL TQLILEGLIN ARIDSHSKIL
     YARDVDQRST TFEKSLQMGR EFQRRAKAMI LRAAVLRNQI HVKSPPREGS QGELTPANSQ
     SRLSTNM