ID   CSN2_ARATH              Reviewed;         439 AA.
AC   Q8W207; Q94A24; Q9ZVD8;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 125.
DE   RecName: Full=COP9 signalosome complex subunit 2;
DE            Short=Signalosome subunit 2;
DE   AltName: Full=Protein FUSCA 12;
GN   Name=CSN2; Synonyms=FUS12; OrderedLocusNames=At2g26990; ORFNames=T20P8.4;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11742986; DOI=10.1093/emboj/20.24.7096;
RA   Fu H., Reis N., Lee Y., Glickman M.H., Vierstra R.;
RT   "Subunit interaction maps for the regulatory particle of the 26S proteasome
RT   and the COP9 signalosome.";
RL   EMBO J. 20:7096-7107(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE, FUNCTION, AND INTERACTION WITH CUL3A; CSN1 AND CSN4.
RX   PubMed=12615944; DOI=10.1105/tpc.009092;
RA   Serino G., Su H., Peng Z., Tsuge T., Wei N., Gu H., Deng X.-W.;
RT   "Characterization of the last subunit of the Arabidopsis COP9 signalosome:
RT   implications for the overall structure and origin of the complex.";
RL   Plant Cell 15:719-731(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   FUNCTION, AND INTERACTION WITH CUL1.
RX   PubMed=11337587; DOI=10.1126/science.1059776;
RA   Schwechheimer C., Serino G., Callis J., Crosby W.L., Lyapina S.,
RA   Deshaies R.J., Gray W.M., Estelle M., Deng X.-W.;
RT   "Interactions of the COP9 signalosome with the E3 ubiquitin ligase
RT   SCF(TIR1) in mediating auxin response.";
RL   Science 292:1379-1382(2001).
CC   -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC       involved in various cellular and developmental processes such as
CC       photomorphogenesis and auxin and jasmonate responses. The CSN complex
CC       is an essential regulator of the ubiquitin (Ubl) conjugation pathway by
CC       mediating the deneddylation of the cullin subunits of SCF-type E3
CC       ligase complexes, leading to decrease the Ubl ligase activity of SCF.
CC       It is involved in repression of photomorphogenesis in darkness by
CC       regulating the activity of COP1-containing Ubl ligase complexes. The
CC       complex is also required for degradation of IAA6 by regulating the
CC       activity of the Ubl ligase SCF-TIR complex.
CC       {ECO:0000269|PubMed:11337587, ECO:0000269|PubMed:12615944}.
CC   -!- SUBUNIT: Component of the CSN complex, probably composed of CSN1, CSN2,
CC       CSN3, CSN4, CSN5 (CSN5A or CSN5B), CSN6 (CSN6A or CSN6B), CSN7 and
CC       CSN8. In the CSN complex, it probably interacts directly with CSN1 and
CC       CSN4. Interacts directly with CUL1 and CUL3A.
CC       {ECO:0000269|PubMed:11337587, ECO:0000269|PubMed:12615944}.
CC   -!- INTERACTION:
CC       Q8W207; P45432: CSN1; NbExp=4; IntAct=EBI-531035, EBI-530996;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CSN2 family. {ECO:0000305}.
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DR   EMBL; AF395058; AAL58101.1; -; mRNA.
DR   EMBL; AC005623; AAC77857.2; -; Genomic_DNA.
DR   EMBL; CP002685; AEC07920.1; -; Genomic_DNA.
DR   EMBL; AY050437; AAK91453.1; -; mRNA.
DR   EMBL; AY133536; AAM91366.1; -; mRNA.
DR   EMBL; AY087622; AAM65163.1; -; mRNA.
DR   PIR; D84667; D84667.
DR   RefSeq; NP_565632.1; NM_128257.4.
DR   AlphaFoldDB; Q8W207; -.
DR   SMR; Q8W207; -.
DR   BioGRID; 2593; 12.
DR   IntAct; Q8W207; 4.
DR   STRING; 3702.AT2G26990.1; -.
DR   iPTMnet; Q8W207; -.
DR   PaxDb; Q8W207; -.
DR   PRIDE; Q8W207; -.
DR   ProteomicsDB; 222620; -.
DR   EnsemblPlants; AT2G26990.1; AT2G26990.1; AT2G26990.
DR   GeneID; 817241; -.
DR   Gramene; AT2G26990.1; AT2G26990.1; AT2G26990.
DR   KEGG; ath:AT2G26990; -.
DR   Araport; AT2G26990; -.
DR   TAIR; locus:2059289; AT2G26990.
DR   eggNOG; KOG1464; Eukaryota.
DR   HOGENOM; CLU_028981_0_0_1; -.
DR   InParanoid; Q8W207; -.
DR   OMA; EEQYDFE; -.
DR   OrthoDB; 1108845at2759; -.
DR   PhylomeDB; Q8W207; -.
DR   PRO; PR:Q8W207; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q8W207; baseline and differential.
DR   Genevisible; Q8W207; AT.
DR   GO; GO:0008180; C:COP9 signalosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; TAS:TAIR.
DR   GO; GO:0030163; P:protein catabolic process; TAS:TAIR.
DR   GO; GO:0000338; P:protein deneddylation; IMP:TAIR.
DR   GO; GO:0009585; P:red, far-red light phototransduction; IEA:UniProtKB-KW.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Developmental protein; Nucleus; Phytochrome signaling pathway;
KW   Reference proteome; Signalosome.
FT   CHAIN           1..439
FT                   /note="COP9 signalosome complex subunit 2"
FT                   /id="PRO_0000120975"
FT   DOMAIN          243..412
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        100
FT                   /note="N -> H (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        251
FT                   /note="A -> E (in Ref. 5; AAK91453/AAM91366)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   439 AA;  51186 MW;  6B0801CDA31D8A48 CRC64;
     MASDADMEDY GFEYSDEEQE EQDVDIENQY YNSKGMVETE PEEALSGFAE VVQMEPEKAD
     WGFKALKQTV KIYYRLGKYK EMMEAYTEML TYIKSAVTRN YSEKCINNIM DFVSGSASQN
     TGLLQEFYQT TLKALEEAKN ERLWFKTNLK LCNIWFDIGE YRRMTKILKE LHKSCQKEDG
     TDDQKKGSQL LEVYAIEIQI YTETKDNKKL KQLYHKALAI KSAIPHPRIM GIIRECGGKM
     HMAERQWEEA ATDFFEAFKN YDEAGNQRRI QCLKYLVLAN MLMESEVNPF DGQEAKPYKN
     DPEILAMTNL IAAYQRNEII EFERILKSNR RTIMDDPFIR NYMEDLLKKV RTQVLLKLIK
     PYTKIGIPFI SKELNVPETD VTELLVSLIL DSRIDGHIDE MNRYLLRGDS GNGRKLHKAV
     DKWNSQLKSL SSNITSRVC