ID   CSN2_BRAOL              Reviewed;          39 AA.
AC   P68353;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=COP9 signalosome complex subunit 2;
DE            Short=Signalosome subunit 2;
DE   AltName: Full=FUSCA protein 12;
DE            Short=FUSCA12;
DE   Flags: Fragments;
GN   Name=CSN2; Synonyms=FUS12;
OS   Brassica oleracea (Wild cabbage).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica.
OX   NCBI_TaxID=3712;
RN   [1]
RP   PROTEIN SEQUENCE OF 1-19 AND 33-39, AND COMPONENT OF THE CSN COMPLEX WITH
RP   CSN1; CSN3; CSN4; CSN5; CSN6; CSN7 AND CSN8.
RX   PubMed=10521526; DOI=10.2307/3871091;
RA   Serino G., Tsuge T., Kwok S., Matsui M., Wei N., Deng X.-W.;
RT   "Arabidopsis cop8 and fus4 mutations define the same gene that encodes
RT   subunit 4 of the COP9 signalosome.";
RL   Plant Cell 11:1967-1980(1999).
RN   [2]
RP   PROTEIN SEQUENCE OF 20-32.
RX   PubMed=12615944; DOI=10.1105/tpc.009092;
RA   Serino G., Su H., Peng Z., Tsuge T., Wei N., Gu H., Deng X.-W.;
RT   "Characterization of the last subunit of the Arabidopsis COP9 signalosome:
RT   implications for the overall structure and origin of the complex.";
RL   Plant Cell 15:719-731(2003).
CC   -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC       involved in various cellular and developmental processes such as
CC       photomorphogenesis and auxin and jasmonate responses. The CSN complex
CC       is an essential regulator of the ubiquitin (Ubl) conjugation pathway by
CC       mediating the deneddylation of the cullin subunits of SCF-type E3
CC       ligase complexes, leading to decrease the Ubl ligase activity of SCF.
CC       It is involved in repression of photomorphogenesis in darkness by
CC       regulating the activity of COP1-containing Ubl ligase complexes (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the CSN complex, probably composed of CSN1, CSN2,
CC       CSN3, CSN4, CSN5 (CSN5A or CSN5B), CSN6 (CSN6A or CSN6B), CSN7 and
CC       CSN8.
CC   -!- INTERACTION:
CC       P68353; P68359: CSN4; NbExp=2; IntAct=EBI-530927, EBI-530932;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC   -!- SIMILARITY: Belongs to the CSN2 family. {ECO:0000305}.
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DR   AlphaFoldDB; P68353; -.
DR   SMR; P68353; -.
DR   IntAct; P68353; 5.
DR   GO; GO:0008180; C:COP9 signalosome; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009585; P:red, far-red light phototransduction; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cytoplasm; Developmental protein; Direct protein sequencing; Nucleus;
KW   Phytochrome signaling pathway; Signalosome.
FT   CHAIN           <1..>39
FT                   /note="COP9 signalosome complex subunit 2"
FT                   /id="PRO_0000120976"
FT   NON_CONS        11..12
FT                   /evidence="ECO:0000305"
FT   NON_CONS        19..20
FT                   /evidence="ECO:0000305"
FT   NON_CONS        32..33
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
FT   NON_TER         39
SQ   SEQUENCE   39 AA;  4865 MW;  BD38114BA373C1CB CRC64;
     KSAVTRNYSE KKNERLWFKK NYDHAGNQRR IQKWNTQLK