ID   CSN2_DANRE              Reviewed;         443 AA.
AC   Q6IQT4;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=COP9 signalosome complex subunit 2;
DE            Short=Signalosome subunit 2;
GN   Name=cops2; Synonyms=csn2; ORFNames=zgc:86624;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the COP9 signalosome complex (CSN), a
CC       complex involved in various cellular and developmental processes. The
CC       CSN complex is an essential regulator of the ubiquitin (Ubl)
CC       conjugation pathway by mediating the deneddylation of the cullin
CC       subunits of E3 ligase complexes, leading to modify the Ubl ligase
CC       activity. {ECO:0000250|UniProtKB:P61201}.
CC   -!- SUBUNIT: Component of the CSN complex, probably composed of cops1,
CC       cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
CC       {ECO:0000250|UniProtKB:P61201}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P61201}. Nucleus
CC       {ECO:0000250|UniProtKB:P61201}.
CC   -!- SIMILARITY: Belongs to the CSN2 family. {ECO:0000305}.
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DR   EMBL; BC071320; AAH71320.1; -; mRNA.
DR   RefSeq; NP_001002055.1; NM_001002055.1.
DR   AlphaFoldDB; Q6IQT4; -.
DR   SMR; Q6IQT4; -.
DR   STRING; 7955.ENSDARP00000012359; -.
DR   PaxDb; Q6IQT4; -.
DR   PRIDE; Q6IQT4; -.
DR   Ensembl; ENSDART00000006124; ENSDARP00000012359; ENSDARG00000004785.
DR   GeneID; 415145; -.
DR   KEGG; dre:415145; -.
DR   CTD; 9318; -.
DR   ZFIN; ZDB-GENE-040625-15; cops2.
DR   eggNOG; KOG1464; Eukaryota.
DR   GeneTree; ENSGT00530000063301; -.
DR   HOGENOM; CLU_028981_0_0_1; -.
DR   InParanoid; Q6IQT4; -.
DR   OMA; RNYQEAG; -.
DR   OrthoDB; 1108845at2759; -.
DR   PhylomeDB; Q6IQT4; -.
DR   TreeFam; TF105738; -.
DR   Reactome; R-DRE-5696394; DNA Damage Recognition in GG-NER.
DR   Reactome; R-DRE-6781823; Formation of TC-NER Pre-Incision Complex.
DR   Reactome; R-DRE-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR   Reactome; R-DRE-8951664; Neddylation.
DR   Reactome; R-DRE-9013422; RHOBTB1 GTPase cycle.
DR   PRO; PR:Q6IQT4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 25.
DR   Bgee; ENSDARG00000004785; Expressed in testis and 29 other tissues.
DR   ExpressionAtlas; Q6IQT4; baseline.
DR   GO; GO:0008180; C:COP9 signalosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   GO; GO:1903507; P:negative regulation of nucleic acid-templated transcription; ISS:UniProtKB.
DR   GO; GO:0000338; P:protein deneddylation; IBA:GO_Central.
DR   InterPro; IPR037750; COPS2.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10678:SF3; PTHR10678:SF3; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..443
FT                   /note="COP9 signalosome complex subunit 2"
FT                   /id="PRO_0000120971"
FT   DOMAIN          254..416
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   443 AA;  51572 MW;  9025F73E9F76B7F3 CRC64;
     MSDMEDDFMC DDEEDYDLEY SEDSNSEPNV DLENQYYNSK ALKEDDPKAA LSSFQKVLEL
     EGEKGEWGFK ALKQMIKINF KLTNFPEMMN RYKQLLTYIR SAVTRNYSEK SINSILDYIS
     TSKQMDLLQE FYETTLEALK DAKNDRLWFK TNTKLGKLYL EREEFGKLQK ILRQLHQSCQ
     TDDGEDDLKK GTQLLEIYAL EIQMYTAQKN NKKLKALYEQ SLHIKSAIPH PLIMGVIREC
     GGKMHLREGE FEKAHTDFFE AFKNYDESGS PRRTTCLKYL VLANMLMKSG INPFDSQEAK
     PYKNDPEILA MTNLVSAYQN NDITEFEKIL KTNHSNIMDD PFIREHIEEL LRNIRTQVLI
     KLIKPYTRIH IPFISKELNI DVADVESLLV QCILDNTING RIDQVNQLLE LDHQKRGGAR
     YTALDKWTNQ LNSLNQAIVS KLA