ID   CSN2_DICDI              Reviewed;         449 AA.
AC   Q54HL6; Q2PQ77;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=COP9 signalosome complex subunit 2;
DE            Short=Signalosome subunit 2;
GN   Name=csn2; ORFNames=DDB_G0289361;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND IDENTIFICATION IN THE CSN COMPLEX.
RX   PubMed=16781008; DOI=10.1016/j.ejcb.2006.04.006;
RA   Rosel D., Kimmel A.R.;
RT   "The COP9 signalosome regulates cell proliferation of Dictyostelium
RT   discoideum.";
RL   Eur. J. Cell Biol. 85:1023-1034(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Essential component of the COP9 signalosome complex (CSN), a
CC       complex involved in various cellular and developmental processes. The
CC       CSN complex is an essential regulator of the ubiquitin (Ubl)
CC       conjugation pathway by mediating the deneddylation of the cullin
CC       subunits of E3 ligase complexes, leading to modify the Ubl ligase
CC       activity.
CC   -!- SUBUNIT: Component of the CSN complex. The holocomplex is comprised of
CC       8 subunits csn1-8. In the complex, it probably interacts directly with
CC       csn1, csn3, csn5, csn6, csn7 and csn8. {ECO:0000269|PubMed:16781008}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSN2 family. {ECO:0000305}.
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DR   EMBL; DQ309430; ABC46694.1; -; mRNA.
DR   EMBL; AAFI02000139; EAL62767.1; -; Genomic_DNA.
DR   RefSeq; XP_636285.1; XM_631193.1.
DR   AlphaFoldDB; Q54HL6; -.
DR   SMR; Q54HL6; -.
DR   STRING; 44689.DDB0233100; -.
DR   PaxDb; Q54HL6; -.
DR   EnsemblProtists; EAL62767; EAL62767; DDB_G0289361.
DR   GeneID; 8627103; -.
DR   KEGG; ddi:DDB_G0289361; -.
DR   dictyBase; DDB_G0289361; csn2.
DR   eggNOG; KOG1464; Eukaryota.
DR   HOGENOM; CLU_028981_0_1_1; -.
DR   InParanoid; Q54HL6; -.
DR   OMA; EEQYDFE; -.
DR   PhylomeDB; Q54HL6; -.
DR   Reactome; R-DDI-5696394; DNA Damage Recognition in GG-NER.
DR   Reactome; R-DDI-6781823; Formation of TC-NER Pre-Incision Complex.
DR   Reactome; R-DDI-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR   Reactome; R-DDI-8951664; Neddylation.
DR   Reactome; R-DDI-9013422; RHOBTB1 GTPase cycle.
DR   PRO; PR:Q54HL6; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0008180; C:COP9 signalosome; IPI:dictyBase.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000338; P:protein deneddylation; IBA:GO_Central.
DR   InterPro; IPR037750; COPS2.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10678:SF3; PTHR10678:SF3; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..449
FT                   /note="COP9 signalosome complex subunit 2"
FT                   /id="PRO_0000327771"
FT   DOMAIN          251..420
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..29
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   449 AA;  52110 MW;  75AA956CFB712FE0 CRC64;
     MSDDEDMMYD DDEYFDDDED QDQNDSESEG VEIENQYYNS KGLIDESIPD AIKSYEKVVD
     LENGEKGEWG FKALKKITKL YFRIGDFDNM LESFKKFLPY TKSSASSNYI EKGINSVLDM
     VSSSNTIELD MIQKVFDLTL KSLLDTKNER VWFRTNLKLA KLLFEKAEYG RLAKILRDLH
     KSCELEDGTD DQKKGSQLVD IYALEIQMYT ETKNNKKLKD LYKKALEIKS AIPHPRIMGI
     IRECGGKMHM AEKEWEKAHT DFFEAFKNYD EAGNSRRIQC LKYLVLACML MLSTINPFDS
     TEAKPYKNDP DILAMTNLVM AYEKNDIYAF EKILKDNRKT IMDDPFIRMY IEDLLRNIRT
     QVLLKLLKPY TRIRISFISK ELNIPSSDVE SLLVSLILDN KIRGSIDQVN QQLELDTAKS
     SAYWKYTSIH KWANQIGQLN GGINNKLVS