ID   CSN2_EMENI              Reviewed;         506 AA.
AC   Q5B3U7; C8VAN5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 2.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=COP9 signalosome complex subunit 2;
DE            Short=Signalosome subunit 2;
GN   Name=csnB; Synonyms=csn2; ORFNames=AN4783;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
RN   [3]
RP   FUNCTION, IDENTIFICATION IN THE CSN COMPLEX, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RX   PubMed=17470786; DOI=10.1073/pnas.0702108104;
RA   Busch S., Schwier E.U., Nahlik K., Bayram O., Helmstaedt K., Draht O.W.,
RA   Krappmann S., Valerius O., Lipscomb W.N., Braus G.H.;
RT   "An eight-subunit COP9 signalosome with an intact JAMM motif is required
RT   for fungal fruit body formation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8089-8094(2007).
CC   -!- FUNCTION: Component of the COP9 signalosome (CSN) complex that acts as
CC       an regulator of the ubiquitin (Ubl) conjugation pathway by mediating
CC       the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-
CC       protein ligase complexes (By similarity). The CSN complex seems to link
CC       protein degradation to sexual development. Required for fruit body
CC       formation. {ECO:0000250, ECO:0000269|PubMed:17470786}.
CC   -!- SUBUNIT: Component of the COP9 signalosome (CSN) complex.
CC       {ECO:0000269|PubMed:17470786}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSN2 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAA60353.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AACD01000081; EAA60353.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BN001303; CBF76790.1; -; Genomic_DNA.
DR   RefSeq; XP_662387.1; XM_657295.1.
DR   AlphaFoldDB; Q5B3U7; -.
DR   SMR; Q5B3U7; -.
DR   DIP; DIP-60926N; -.
DR   IntAct; Q5B3U7; 4.
DR   STRING; 162425.CADANIAP00005639; -.
DR   EnsemblFungi; CBF76790; CBF76790; ANIA_04783.
DR   EnsemblFungi; EAA60353; EAA60353; AN4783.2.
DR   GeneID; 2872575; -.
DR   KEGG; ani:AN4783.2; -.
DR   VEuPathDB; FungiDB:AN4783; -.
DR   eggNOG; KOG1464; Eukaryota.
DR   HOGENOM; CLU_028981_0_1_1; -.
DR   InParanoid; Q5B3U7; -.
DR   OMA; EEQYDFE; -.
DR   OrthoDB; 1108845at2759; -.
DR   Proteomes; UP000000560; Chromosome III.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0008180; C:COP9 signalosome; IDA:AspGD.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:EnsemblFungi.
DR   GO; GO:0070791; P:cleistothecium development; IMP:AspGD.
DR   GO; GO:0000338; P:protein deneddylation; IBA:GO_Central.
DR   InterPro; IPR037750; COPS2.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10678:SF3; PTHR10678:SF3; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..506
FT                   /note="COP9 signalosome complex subunit 2"
FT                   /id="PRO_0000314740"
FT   DOMAIN          252..420
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          482..506
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   506 AA;  58113 MW;  4F199DDBE717D213 CRC64;
     MSDDDDFMHD SADEEYDFEY EDADDDETGD IGIENKYYNA KQIKVDNPEE AIDEFLGVPA
     LEQDKGDWGF KGLKQAIKLE FKLGRYSDAV EHYRELLTYV KSAVTRNYSE KSINNMLDYI
     EKGSDDEKAY QCMEEFYSLT LNSFQNTNNE RLWLKTNIKL ARLWLERREY GQLSKKVREL
     HRACQREDGS DDPSKGTYLL ELYALEIQMY AETKNNKRLK ALYQRALRVR SAVPHPKIMG
     IIRECGGKMH MSEENWEEAQ SDFFESFRNY DEAGSMQRIQ VLKYLVLTTM LMKSDINPFH
     SQETKPYKTD PRISAMTDLV DAFQRDDIHA YEEVLSKNPD VLADPFIAEN IDEVSRNMRT
     KAILKLIAPY TRFTLSFISK HIKISVTEAQ DILSFLILDK KLNAKIDQES GTVVVESASD
     VERLRSVEEW NESLRTLWQV TLKDGDGFKN DDVSQPTGIG MRGPLLYQSG LDDDTAGLLR
     SSGHRFRRGG KGSKAGGGLG MKTGLF