CSN2_NEUCR
ID CSN2_NEUCR Reviewed; 490 AA.
AC Q7SI58;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=COP9 signalosome complex subunit 2;
DE Short=Signalosome subunit 2;
GN Name=csn-2; ORFNames=B22I21.160, NCU00593;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY,
RP IDENTIFICATION IN THE COP9 SIGNALOSOME COMPLEX, AND FUNCTION OF THE COP9
RP SIGNALOSOME COMPLEX.
RX PubMed=15961524; DOI=10.1101/gad.1322205;
RA He Q., Cheng P., He Q., Liu Y.;
RT "The COP9 signalosome regulates the Neurospora circadian clock by
RT controlling the stability of the SCFFWD-1 complex.";
RL Genes Dev. 19:1518-1531(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12655011; DOI=10.1093/nar/gkg293;
RA Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT genome sequence.";
RL Nucleic Acids Res. 31:1944-1954(2003).
CC -!- FUNCTION: Component of the COP9 signalosome (CSN) complex that acts as
CC an regulator of the ubiquitin (Ubl) conjugation pathway by mediating
CC the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-
CC protein ligase complexes (By similarity). The CSN complex is involved
CC in the regulation of the circadian clock through its control of the
CC stability of the SCF(FWD-1) complex. {ECO:0000250,
CC ECO:0000269|PubMed:15961524}.
CC -!- SUBUNIT: Component of the COP9 signalosome (CSN) complex.
CC {ECO:0000269|PubMed:15961524}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CSN2 family. {ECO:0000305}.
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DR EMBL; DQ242511; ABB36581.1; -; mRNA.
DR EMBL; CM002236; EAA36497.1; -; Genomic_DNA.
DR EMBL; BX842641; CAE76602.1; -; Genomic_DNA.
DR RefSeq; XP_965733.1; XM_960640.2.
DR AlphaFoldDB; Q7SI58; -.
DR SMR; Q7SI58; -.
DR STRING; 5141.EFNCRP00000000985; -.
DR EnsemblFungi; EAA36497; EAA36497; NCU00593.
DR GeneID; 3881875; -.
DR KEGG; ncr:NCU00593; -.
DR VEuPathDB; FungiDB:NCU00593; -.
DR HOGENOM; CLU_028981_0_1_1; -.
DR InParanoid; Q7SI58; -.
DR Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR GO; GO:0008180; C:COP9 signalosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:EnsemblFungi.
DR GO; GO:0000338; P:protein deneddylation; IBA:GO_Central.
DR InterPro; IPR037750; COPS2.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10678:SF3; PTHR10678:SF3; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50250; PCI; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT CHAIN 1..490
FT /note="COP9 signalosome complex subunit 2"
FT /id="PRO_0000314741"
FT DOMAIN 250..418
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 469..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..29
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 490 AA; 56958 MW; 9206982A584087C3 CRC64;
MSDDDFMQDS DQEYDFEYED DEEEDTGDVD IENKYYNAKQ TKTSDPEEAL QEFLSIPPLE
QEKGDWGFKA LKQAIKLEFK LKRYQEATEH YEELLTYVKS AVTRNYSEKS IDNMLNYIEK
GYDDPKAVQC IEKFYSLTLQ CFQSTNNERL WLKTNIKLAR LLLDRKDYHA VARKLRELHN
ACRKSDGTDD PSKGTYSLEI YALEIQMYSE TRNNNQLKVL YQKALKVRSA VPHPKIQGVI
RECGGKMHMS EENWKEAQSD FFEAFRNYDE AGDLRRIQVL KYLLLTTMLM KSDINPFDSQ
EMKPYRNDPR IFAMTELVDA YQRDDIYRYE DVLQKNTDLL ADPFIAENID EVTRNMRTKG
VVKLIAPYTR MRISWLAERL RITEPEVMDI LSFLIVDGRV KGRIDEHKGV LELESREDAD
HVQAITVLSE AVGNLFNAVF KSTDGFQPGQ GDFMNSMADQ SADIGSLDDT MRSMGSGKRG
RRVGLTQRAY
