ID   CSN2_XENLA              Reviewed;         441 AA.
AC   Q6IR75;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=COP9 signalosome complex subunit 2;
DE            Short=Signalosome subunit 2;
DE   Flags: Fragment;
GN   Name=csn2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the COP9 signalosome complex (CSN), a
CC       complex involved in various cellular and developmental processes. The
CC       CSN complex is an essential regulator of the ubiquitin (Ubl)
CC       conjugation pathway by mediating the deneddylation of the cullin
CC       subunits of E3 ligase complexes, leading to modify the Ubl ligase
CC       activity (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the CSN complex, probably composed of cops1,
CC       cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
CC       {ECO:0000250|UniProtKB:P61201}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSN2 family. {ECO:0000305}.
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DR   EMBL; BC071025; AAH71025.1; -; mRNA.
DR   AlphaFoldDB; Q6IR75; -.
DR   SMR; Q6IR75; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0008180; C:COP9 signalosome; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR037750; COPS2.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10678:SF3; PTHR10678:SF3; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           <1..441
FT                   /note="COP9 signalosome complex subunit 2"
FT                   /id="PRO_0000120972"
FT   DOMAIN          252..414
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..24
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   441 AA;  51336 MW;  C461EAD82CA21A59 CRC64;
     DMEDDFMCDD EEDYDLEYSE DSNSEPNVDL ENQYYNSKAL KEDDPKAALS SFQKVLELEG
     EKGEWGFKAL KQMIKINFKL GNYPEMMNRY KQLLTYIRSA VTRNYSEKSI NSILDYISTS
     KQMDLLQEFY ETTLDALKDA KNDRLWFKTN TKLGKLYLER EEYGKLQKIL RQLHQSCQTD
     DGEDDLKKGT QLLEIYALEI QMYTAQKNNK KLKALYEQSL HIKSAIPHPL IMGVIRECGG
     KMHLREGEFE KAHTDFFEAF KNYDESGSPR RTTCLKYLVL ANMLMKSGIN PFDSQEAKPY
     KNDPEILAMT NLVSAYQNND ITEFEKILKT NHSNIMDDPF IREHIEELLR NIRTQVLIKL
     IKPYTRIHIP FISKELNIDV ADVESLLVQC ILDNTIHGRI DQVNQLLELD HQKRGGARYT
     ALDKWTNQLN SLNQAVVSKL A