ID   CSN3_BOVIN              Reviewed;         423 AA.
AC   A6H7B5;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=COP9 signalosome complex subunit 3;
DE            Short=SGN3;
DE            Short=Signalosome subunit 3;
GN   Name=COPS3; Synonyms=CSN3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC       involved in various cellular and developmental processes (By
CC       similarity). The CSN complex is an essential regulator of the ubiquitin
CC       (Ubl) conjugation pathway by mediating the deneddylation of the cullin
CC       subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl
CC       ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By
CC       similarity). The complex is also involved in phosphorylation of
CC       p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP,
CC       possibly via its association with CK2 and PKD kinases (By similarity).
CC       CSN-dependent phosphorylation of TP53 and JUN promotes and protects
CC       degradation by the Ubl system, respectively (By similarity). Essential
CC       to maintain the survival of epiblast cells and thus the development of
CC       the postimplantation embryo (By similarity).
CC       {ECO:0000250|UniProtKB:O88543, ECO:0000250|UniProtKB:Q9UNS2}.
CC   -!- SUBUNIT: Component of the CSN complex, composed of COPS1/GPS1, COPS2,
CC       COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9
CC       (By similarity). In the complex, it probably interacts directly with
CC       COPS1, COPS4, COPS8 and COPS9 (By similarity). Interacts with CK2 and
CC       PKD (By similarity). Interacts with the translation initiation factor
CC       EIF3S6 and IKBKG (By similarity). Interacts with ERCC6 (By similarity).
CC       {ECO:0000250|UniProtKB:Q9UNS2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UNS2}. Nucleus
CC       {ECO:0000250|UniProtKB:Q9UNS2}.
CC   -!- SIMILARITY: Belongs to the CSN3 family. {ECO:0000305}.
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DR   EMBL; BC146183; AAI46184.1; -; mRNA.
DR   RefSeq; NP_001092374.1; NM_001098904.1.
DR   AlphaFoldDB; A6H7B5; -.
DR   SMR; A6H7B5; -.
DR   STRING; 9913.ENSBTAP00000025255; -.
DR   PaxDb; A6H7B5; -.
DR   PeptideAtlas; A6H7B5; -.
DR   PRIDE; A6H7B5; -.
DR   Ensembl; ENSBTAT00000025255; ENSBTAP00000025255; ENSBTAG00000018973.
DR   GeneID; 507932; -.
DR   KEGG; bta:507932; -.
DR   CTD; 8533; -.
DR   VEuPathDB; HostDB:ENSBTAG00000018973; -.
DR   VGNC; VGNC:27600; COPS3.
DR   eggNOG; KOG2582; Eukaryota.
DR   GeneTree; ENSGT00940000153653; -.
DR   HOGENOM; CLU_028825_0_1_1; -.
DR   InParanoid; A6H7B5; -.
DR   OMA; NHYHDLV; -.
DR   OrthoDB; 929822at2759; -.
DR   TreeFam; TF101146; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000018973; Expressed in corpus luteum and 107 other tissues.
DR   ExpressionAtlas; A6H7B5; baseline and differential.
DR   GO; GO:0008180; C:COP9 signalosome; IEA:UniProtKB-KW.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR   GO; GO:0000338; P:protein deneddylation; IEA:Ensembl.
DR   GO; GO:1902162; P:regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; IEA:Ensembl.
DR   InterPro; IPR037753; CSN3.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10758:SF1; PTHR10758:SF1; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome;
KW   Signalosome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UNS2"
FT   CHAIN           2..423
FT                   /note="COP9 signalosome complex subunit 3"
FT                   /id="PRO_0000312644"
FT   DOMAIN          197..365
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          402..423
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UNS2"
FT   MOD_RES         407
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O88543"
FT   MOD_RES         410
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UNS2"
FT   MOD_RES         423
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UNS2"
SQ   SEQUENCE   423 AA;  47799 MW;  1476ED0D3DE6782F CRC64;
     MASALEQFVN SVRQLSAQGQ MTQLCELINK SGELLAKNLS HLDTVLGALD VQEHSLGVLA
     VLFVKFSMPS VPDFETLFSQ VQLFISTCNG EHIRYATDTF AGLCHQLTNA LVERKQPLRG
     IGVLRQAIDK MQMNTNQLTS VHADLCQLCL LAKCFKPALP YLDVDMVDIC KENGAYDAKH
     FLCYYYYGGM VYTGLKNFER ALYFYEQAIT TPAMAVSHIM LESYKKYILV SLILLGKVQQ
     LPKYTSQIVG RFIKPLSNAY HELAQVYSTN NPSELRSLVT KHSEIFTRDN NMGLVKQCLS
     SLYKKNIQRL TKTFLTLSLQ DMASRVQLSG PQEAEKYVLH MIEDGEIFAS INQKDGMVSF
     HDNPEKYNNP AMLHNIDQEM LKCIELDERL KAMDQEITVN PQFVQKSMGS QEDDSGNKPS
     SYS