ID   CSN3_CHICK              Reviewed;         423 AA.
AC   Q5ZJF1;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=COP9 signalosome complex subunit 3;
DE            Short=Signalosome subunit 3;
GN   Name=COPS3; Synonyms=CSN3; ORFNames=RCJMB04_18l12;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC       involved in various cellular and developmental processes (By
CC       similarity). The CSN complex is an essential regulator of the ubiquitin
CC       (Ubl) conjugation pathway by mediating the deneddylation of the cullin
CC       subunits of E3 ligase complexes, leading to modify the Ubl ligase
CC       activity (By similarity). {ECO:0000250|UniProtKB:Q9UNS2}.
CC   -!- SUBUNIT: Component of the CSN complex, probably composed of COPS1,
CC       COPS2, COPS3, COPS4, COPS5, COPS6, COPS7, COPS8 and COPS9.
CC       {ECO:0000250|UniProtKB:Q9UNS2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UNS2}. Nucleus
CC       {ECO:0000250|UniProtKB:Q9UNS2}.
CC   -!- SIMILARITY: Belongs to the CSN3 family. {ECO:0000305}.
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DR   EMBL; AJ720483; CAG32142.1; -; mRNA.
DR   RefSeq; NP_001006163.1; NM_001006163.1.
DR   AlphaFoldDB; Q5ZJF1; -.
DR   SMR; Q5ZJF1; -.
DR   STRING; 9031.ENSGALP00000007709; -.
DR   PaxDb; Q5ZJF1; -.
DR   Ensembl; ENSGALT00000085512; ENSGALP00000064004; ENSGALG00000004834.
DR   GeneID; 416504; -.
DR   KEGG; gga:416504; -.
DR   CTD; 8533; -.
DR   VEuPathDB; HostDB:geneid_416504; -.
DR   eggNOG; KOG2582; Eukaryota.
DR   GeneTree; ENSGT00940000153653; -.
DR   HOGENOM; CLU_028825_0_1_1; -.
DR   InParanoid; Q5ZJF1; -.
DR   OMA; NHYHDLV; -.
DR   OrthoDB; 929822at2759; -.
DR   PhylomeDB; Q5ZJF1; -.
DR   TreeFam; TF101146; -.
DR   Reactome; R-GGA-5696394; DNA Damage Recognition in GG-NER.
DR   Reactome; R-GGA-6781823; Formation of TC-NER Pre-Incision Complex.
DR   Reactome; R-GGA-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR   PRO; PR:Q5ZJF1; -.
DR   Proteomes; UP000000539; Chromosome 14.
DR   Bgee; ENSGALG00000004834; Expressed in muscle tissue and 13 other tissues.
DR   GO; GO:0008180; C:COP9 signalosome; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0000338; P:protein deneddylation; IEA:Ensembl.
DR   GO; GO:1902162; P:regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; IEA:Ensembl.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   InterPro; IPR037753; CSN3.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10758:SF1; PTHR10758:SF1; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..423
FT                   /note="COP9 signalosome complex subunit 3"
FT                   /id="PRO_0000312648"
FT   DOMAIN          197..365
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          402..423
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   423 AA;  47962 MW;  DD4364E75B5C905B CRC64;
     MASALEQFVN SVRQLSAQGQ MTQLCELINK SGELLAKNLS HLDTVLGALD VQEHSLGVLA
     VLFVKFSMPS IPDFETLFSQ VQLFISTCNG EHIRYATDTF AGLCHQLTNA LVERKQPLRG
     ISILRQAIDK MQMNTNQLTS IHADLCQLCL LAKCFKPALP YLDVDMMDIC KENGAYDAKH
     FLCYYYYGGM IYTGLKNFER ALYFYEQAIT TPAMAVSHIM LESYKKYILV SLILLGKVQQ
     LPKYTSQIVG RFIKPLSNAY HELAQVYSTN KPSELRNLVN KHSETFTRDN NMGLVKQCLS
     SLYKKNIQRL TKTFLTLSLQ DMASRVQLSG PQEAEKYVLH MIEDGEIFAS INQKDGMVCF
     HDNPEKYNNP AMLHNIDQEM LKCIELDERL KAMDQEITVN PQFVQKSMGS QEDDSGTKPS
     SYS