ID   CSN3_DANRE              Reviewed;         423 AA.
AC   Q6P2U9; Q7ZVT8;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=COP9 signalosome complex subunit 3;
DE            Short=Signalosome subunit 3;
GN   Name=cops3; Synonyms=csn3; ORFNames=wu:fc32a02;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC       involved in various cellular and developmental processes (By
CC       similarity). The CSN complex is an essential regulator of the ubiquitin
CC       (Ubl) conjugation pathway by mediating the deneddylation of the cullin
CC       subunits of E3 ligase complexes, leading to modify the Ubl ligase
CC       activity (By similarity). {ECO:0000250|UniProtKB:Q9UNS2}.
CC   -!- SUBUNIT: Component of the CSN complex, probably composed of cops1,
CC       cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
CC       {ECO:0000250|UniProtKB:Q9UNS2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UNS2}. Nucleus
CC       {ECO:0000250|UniProtKB:Q9UNS2}.
CC   -!- SIMILARITY: Belongs to the CSN3 family. {ECO:0000305}.
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DR   EMBL; BC045415; AAH45415.1; -; mRNA.
DR   EMBL; BC064288; AAH64288.1; -; mRNA.
DR   RefSeq; NP_955979.1; NM_199685.1.
DR   AlphaFoldDB; Q6P2U9; -.
DR   SMR; Q6P2U9; -.
DR   PaxDb; Q6P2U9; -.
DR   GeneID; 335720; -.
DR   KEGG; dre:335720; -.
DR   CTD; 8533; -.
DR   ZFIN; ZDB-GENE-030131-7660; cops3.
DR   eggNOG; KOG2582; Eukaryota.
DR   InParanoid; Q6P2U9; -.
DR   OrthoDB; 929822at2759; -.
DR   PhylomeDB; Q6P2U9; -.
DR   Reactome; R-DRE-5696394; DNA Damage Recognition in GG-NER.
DR   Reactome; R-DRE-6781823; Formation of TC-NER Pre-Incision Complex.
DR   Reactome; R-DRE-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR   Reactome; R-DRE-8951664; Neddylation.
DR   PRO; PR:Q6P2U9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0008180; C:COP9 signalosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   InterPro; IPR037753; CSN3.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10758:SF1; PTHR10758:SF1; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..423
FT                   /note="COP9 signalosome complex subunit 3"
FT                   /id="PRO_0000120980"
FT   DOMAIN          197..365
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          402..423
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        36
FT                   /note="A -> S (in Ref. 1; AAH45415)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        292
FT                   /note="T -> S (in Ref. 1; AAH45415)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   423 AA;  47907 MW;  D3E98EB62DD7D663 CRC64;
     MASALEQFVN NVRQLSAQGQ MTQLCELINK SGELLAKNLS HLDTVLGALD IQEHSLGVLA
     VLFVKFSMPN IPDFETLFSQ VQLFISTCNG EHIRYATDTF AGLCHQLTNA LVERKQPLRG
     ISILKQAIDK MQMNTNQLTS VHADLCQLCL LAKCFKPAVP FLELDMMDIC KENGAYDAKH
     FLCYYYYGGM IYTGLKNFER ALYFFEQAIT TPAMAVSHIM LEAYKKYILV SLILHGKVQQ
     LPKYTSQIVG RFIKPLSNAY HELAQIYATN NPAELRALVN KHSETFTRDN NTGLVKQCLS
     SLYKKNIQRL TKTFLTLSLQ DMASRVQLSG PQEAEKYVLH MIEDGEIYAS INQKDGMVCF
     HDNPEKYNNP AMLHKIDQEM LKCIELDEKL KSMDQEITVN PQFVQKSMGT QEDDVGSKTS
     SYS