ID   CSN3_DICDI              Reviewed;         418 AA.
AC   Q54E53; Q2PQ76;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=COP9 signalosome complex subunit 3;
DE            Short=Signalosome subunit 3;
GN   Name=csn3; ORFNames=DDB_G0291848;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND IDENTIFICATION IN THE CSN COMPLEX.
RX   PubMed=16781008; DOI=10.1016/j.ejcb.2006.04.006;
RA   Rosel D., Kimmel A.R.;
RT   "The COP9 signalosome regulates cell proliferation of Dictyostelium
RT   discoideum.";
RL   Eur. J. Cell Biol. 85:1023-1034(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC       involved in various cellular and developmental processes. The CSN
CC       complex is an essential regulator of the ubiquitin (Ubl) conjugation
CC       pathway by mediating the deneddylation of the cullin subunits of E3
CC       ligase complexes, leading to modify the Ubl ligase activity.
CC   -!- SUBUNIT: Component of the CSN complex. The holocomplex is comprised of
CC       8 subunits csn1-8. In the complex, it probably interacts directly with
CC       csn2 and csn5. {ECO:0000269|PubMed:16781008}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSN3 family. {ECO:0000305}.
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DR   EMBL; DQ309431; ABC46695.1; -; mRNA.
DR   EMBL; AAFI02000185; EAL61545.1; -; Genomic_DNA.
DR   RefSeq; XP_629934.1; XM_629932.1.
DR   AlphaFoldDB; Q54E53; -.
DR   SMR; Q54E53; -.
DR   STRING; 44689.DDB0233101; -.
DR   PaxDb; Q54E53; -.
DR   EnsemblProtists; EAL61545; EAL61545; DDB_G0291848.
DR   GeneID; 8628339; -.
DR   KEGG; ddi:DDB_G0291848; -.
DR   dictyBase; DDB_G0291848; csn3.
DR   eggNOG; KOG2582; Eukaryota.
DR   HOGENOM; CLU_028825_0_1_1; -.
DR   InParanoid; Q54E53; -.
DR   OMA; NHYHDLV; -.
DR   PhylomeDB; Q54E53; -.
DR   Reactome; R-DDI-5696394; DNA Damage Recognition in GG-NER.
DR   Reactome; R-DDI-6781823; Formation of TC-NER Pre-Incision Complex.
DR   Reactome; R-DDI-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR   Reactome; R-DDI-8951664; Neddylation.
DR   PRO; PR:Q54E53; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0008180; C:COP9 signalosome; IPI:dictyBase.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR037753; CSN3.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10758:SF1; PTHR10758:SF1; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..418
FT                   /note="COP9 signalosome complex subunit 3"
FT                   /id="PRO_0000327772"
FT   DOMAIN          186..356
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   418 AA;  47322 MW;  E93561D583C03AA5 CRC64;
     MDSFVLDAQN PNPKNLKNLL KYEEQLERQH VSLDNILGAL DVRNHSLGQL LVLKAKGSDQ
     GKNRSVFIDQ CNNFFRNCNV EQVRLAPAQL SQLSKFYTEA LYELKQPIRG VAVLKDALNI
     LSDNKPTTTL TPIHTDFLQL CILSKCYHQA LPLIESNITH INPEQSSIAI KDILCYFYYS
     GIIFTAFKKY KKAIEAFKFV ITAPASALSA ITVEAYKKYL IVYLIQFGSV QHFPKCTPAV
     VQRNIKSHCK PYTEFVQSFS NGNINDIMNK ASSGAEFFQK DSNWGLVKLS IKSTYRRNIK
     KLTQTFMTLS INDIAEKVSL PKAKAEQFVL KMIEEGEIFA TINQKDGMVT FDECFEDFSG
     PTILNDLDRN INNIVGLESK IKEMDEKISL SNNYLKKLAS GKNTGQLSQY EDPMEDIS