ID   CSN3_NEUCR              Reviewed;         497 AA.
AC   Q7S7G7; Q6MW17;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 2.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=COP9 signalosome complex subunit 3;
DE            Short=Signalosome subunit 3;
GN   Name=csn-3; ORFNames=G11A3.070, NCU01408;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE COP9 SIGNALOSOME
RP   COMPLEX, AND FUNCTION OF THE COP9 SIGNALOSOME COMPLEX.
RX   PubMed=15961524; DOI=10.1101/gad.1322205;
RA   He Q., Cheng P., He Q., Liu Y.;
RT   "The COP9 signalosome regulates the Neurospora circadian clock by
RT   controlling the stability of the SCFFWD-1 complex.";
RL   Genes Dev. 19:1518-1531(2005).
CC   -!- FUNCTION: Component of the COP9 signalosome (CSN) complex that acts as
CC       an regulator of the ubiquitin (Ubl) conjugation pathway by mediating
CC       the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-
CC       protein ligase complexes (By similarity). The CSN complex is involved
CC       in the regulation of the circadian clock through its control of the
CC       stability of the SCF(FWD1) complex. {ECO:0000250,
CC       ECO:0000269|PubMed:15961524}.
CC   -!- SUBUNIT: Component of the COP9 signalosome (CSN) complex.
CC       {ECO:0000269|PubMed:15961524}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSN3 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CM002240; EAA31595.2; -; Genomic_DNA.
DR   EMBL; BX842619; CAE76134.1; -; Genomic_DNA.
DR   RefSeq; XP_960831.2; XM_955738.3.
DR   AlphaFoldDB; Q7S7G7; -.
DR   SMR; Q7S7G7; -.
DR   STRING; 5141.EFNCRP00000004201; -.
DR   EnsemblFungi; EAA31595; EAA31595; NCU01408.
DR   GeneID; 3876978; -.
DR   KEGG; ncr:NCU01408; -.
DR   VEuPathDB; FungiDB:NCU01408; -.
DR   HOGENOM; CLU_028825_1_0_1; -.
DR   InParanoid; Q7S7G7; -.
DR   OMA; NHYHDLV; -.
DR   Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR   GO; GO:0008180; C:COP9 signalosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   InterPro; IPR037753; CSN3.
DR   InterPro; IPR000717; PCI_dom.
DR   PANTHER; PTHR10758:SF1; PTHR10758:SF1; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..497
FT                   /note="COP9 signalosome complex subunit 3"
FT                   /id="PRO_0000314743"
FT   DOMAIN          233..408
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   497 AA;  55218 MW;  2BE2F7C04E5F17D4 CRC64;
     MDARLTVLTA FPPAAGIDNE EYYQNSQQHA KRVRELVRDN AQWIRESADD ILKHVNPAVY
     SLSYLMILEF LLQSPGWTSQ QAHESLASYM AQFFLQFDAR QIRCKGSTWS DVLKEAYSER
     GLFPASVAVE LVTAALLRLD PSGSIITSHH CNLVELAYNT GNVGALLPLI EKPIIYMPAK
     GMSTAQPLCD MSLPPPAYIN PDSQLTDALT SAAVLQYDFL CGLCFIERRM WQQAFDAFER
     CVTYPTRDGG CSKIMTEAYN KWILVGLLLT GKPPTLPETT SQAAKKIFAT QGKPYKLFAQ
     AFKSETAGDL VREFEVINSE LLPNEGNVEL AKLVLAHYQR WQIINLRNIY TNISLEKIQE
     RTQSAETGAP LPTVEAVDQL VQSMIADGSL QGAIERPKDG SPAYLTFLSS PAQGMSEVEF
     SAQVNKVMQG IKALEPIIEA TNKRLASNRE YISHTVKRQF DAAREHKLGL QSAGGGFEES
     SFHIEEEEDL MSGLPAH