ID   CSN3_XENLA              Reviewed;         423 AA.
AC   Q7ZTN8;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=COP9 signalosome complex subunit 3;
DE            Short=Signalosome subunit 3;
GN   Name=cops3; Synonyms=csn3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC       involved in various cellular and developmental processes (By
CC       similarity). The CSN complex is an essential regulator of the ubiquitin
CC       (Ubl) conjugation pathway by mediating the deneddylation of the cullin
CC       subunits of E3 ligase complexes, leading to modify the Ubl ligase
CC       activity (By similarity). {ECO:0000250|UniProtKB:Q9UNS2}.
CC   -!- SUBUNIT: Component of the CSN complex, probably composed of cops1,
CC       cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
CC       {ECO:0000250|UniProtKB:Q9UNS2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UNS2}. Nucleus
CC       {ECO:0000250|UniProtKB:Q9UNS2}.
CC   -!- SIMILARITY: Belongs to the CSN3 family. {ECO:0000305}.
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DR   EMBL; BC044034; AAH44034.1; -; mRNA.
DR   RefSeq; NP_001080121.1; NM_001086652.1.
DR   AlphaFoldDB; Q7ZTN8; -.
DR   SMR; Q7ZTN8; -.
DR   DNASU; 379813; -.
DR   GeneID; 379813; -.
DR   KEGG; xla:379813; -.
DR   CTD; 379813; -.
DR   Xenbase; XB-GENE-944163; cops3.L.
DR   OMA; CLKARIH; -.
DR   OrthoDB; 929822at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 379813; Expressed in muscle tissue and 19 other tissues.
DR   GO; GO:0008180; C:COP9 signalosome; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR037753; CSN3.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10758:SF1; PTHR10758:SF1; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..423
FT                   /note="COP9 signalosome complex subunit 3"
FT                   /id="PRO_0000120981"
FT   DOMAIN          197..365
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          401..423
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   423 AA;  47795 MW;  A5DE8F686194D861 CRC64;
     MASALEQFVN SVRQLSSQGQ MTQLCELINK SGELLAKNLS HLDTVLGALD VQEHSLGVLA
     VLFVKFSMPS IPDFETLFSQ VQLFISTCNG EHIRYATDTF AGLCHQLTNA LVERKQPLRG
     ICVIRQAIDK MQMNANQLTS IHGDLCQLSL LAKCFKPALA YLDVDMMDIC KENGAYDAKP
     FLCYYYYGGM IYTGLKNFER AMYFYEQAIT TPAMAVSHIM LEAYKKYILV SLILHGKVQQ
     LPKYTSQVVG RFIKPLSNAY HELAQVYSTN NPAELRNLVS KHNETFTRDN NMGLVKQCLS
     SLYKKNIQRL TKTFLTLSLQ DMASRVQLSG AQEAEKYVLY MIEDGEIFAS INQKDGMVCF
     HDSPEKYNNP AMLHNIDQEM LRCIDLDDRL KAMDQEITVN PQFVQKSMGS QEDDSGSKPS
     SYS