ID   CSN3_XENTR              Reviewed;         423 AA.
AC   Q28IV6;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=COP9 signalosome complex subunit 3;
DE            Short=Signalosome subunit 3;
GN   Name=cops3; Synonyms=csn3; ORFNames=TNeu097m08.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC       involved in various cellular and developmental processes (By
CC       similarity). The CSN complex is an essential regulator of the ubiquitin
CC       (Ubl) conjugation pathway by mediating the deneddylation of the cullin
CC       subunits of E3 ligase complexes, leading to modify the Ubl ligase
CC       activity (By similarity). {ECO:0000250|UniProtKB:Q9UNS2}.
CC   -!- SUBUNIT: Component of the CSN complex, probably composed of cops1,
CC       cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
CC       {ECO:0000250|UniProtKB:Q9UNS2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UNS2}. Nucleus
CC       {ECO:0000250|UniProtKB:Q9UNS2}.
CC   -!- SIMILARITY: Belongs to the CSN3 family. {ECO:0000305}.
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DR   EMBL; CR760202; CAJ83043.1; -; mRNA.
DR   RefSeq; NP_001017238.1; NM_001017238.2.
DR   AlphaFoldDB; Q28IV6; -.
DR   SMR; Q28IV6; -.
DR   PaxDb; Q28IV6; -.
DR   Ensembl; ENSXETT00000012648; ENSXETP00000012648; ENSXETG00000005742.
DR   GeneID; 549992; -.
DR   KEGG; xtr:549992; -.
DR   CTD; 8533; -.
DR   Xenbase; XB-GENE-944158; cops3.
DR   eggNOG; KOG2582; Eukaryota.
DR   HOGENOM; CLU_028825_0_1_1; -.
DR   InParanoid; Q28IV6; -.
DR   OMA; CLKARIH; -.
DR   OrthoDB; 929822at2759; -.
DR   PhylomeDB; Q28IV6; -.
DR   TreeFam; TF101146; -.
DR   Reactome; R-XTR-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR   Reactome; R-XTR-8951664; Neddylation.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000005742; Expressed in skeletal muscle tissue and 14 other tissues.
DR   GO; GO:0008180; C:COP9 signalosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   InterPro; IPR037753; CSN3.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10758:SF1; PTHR10758:SF1; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..423
FT                   /note="COP9 signalosome complex subunit 3"
FT                   /id="PRO_0000312649"
FT   DOMAIN          197..365
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          403..423
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   423 AA;  47818 MW;  C2C401E0349E0E13 CRC64;
     MASALEQFVN SVRQLSSQGQ MTQLCELINK SGELLAKNLS HLDTVLGALD VQEHSLGVLA
     VLFVKFSMPS IPDFETLFSQ VQLFISTCNG EHIRYATDTF AGLCHQLTNA LVERKQPLRG
     ICVLRQAIDK MQMNANQLTS IHADLCQLSL LAKCFKPALA YLDVDMMDIC KENGAYDAKP
     FLCYYYYGGM IYTGLKNFER ALYFYEQAIT TPAMAVSHIM LEAYKKYILV SLILHGKVQQ
     LPKYTSQIVG RFIKPLSNAY HELAQVYSTN NPAELRNLVS KHNETFTRDN NMGLVKQCLS
     SLYKKNIQRL TKTFLTLSLQ DMASRVQLSG AQEAEKYVLY MIEDGEIFAS INQKDGMVCF
     HDNPEKYNNP AMLHNIDQEM LRCIDLDDRL KAMDQEITVN PQFVQKSMGS QDDDSGSKPS
     SYS