ID   CSN4_DANRE              Reviewed;         406 AA.
AC   Q6P0H6; Q6PHJ7;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=COP9 signalosome complex subunit 4;
DE            Short=Signalosome subunit 4;
GN   Name=cops4; Synonyms=csn4; ORFNames=zgc:77137;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC       involved in various cellular and developmental processes (By
CC       similarity). The CSN complex is an essential regulator of the ubiquitin
CC       (Ubl) conjugation pathway by mediating the deneddylation of the cullin
CC       subunits of E3 ligase complexes, leading to modify the Ubl ligase
CC       activity (By similarity). {ECO:0000250|UniProtKB:Q9BT78}.
CC   -!- SUBUNIT: Component of the CSN complex, probably composed of cops1,
CC       cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
CC       {ECO:0000250|UniProtKB:Q9BT78}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BT78}. Nucleus
CC       {ECO:0000250|UniProtKB:Q9BT78}. Cytoplasmic vesicle, secretory vesicle,
CC       synaptic vesicle {ECO:0000250|UniProtKB:Q9BT78}.
CC   -!- SIMILARITY: Belongs to the CSN4 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC056527; AAH56527.1; -; mRNA.
DR   EMBL; BC065617; AAH65617.1; -; mRNA.
DR   RefSeq; NP_991119.1; NM_205556.1.
DR   AlphaFoldDB; Q6P0H6; -.
DR   SMR; Q6P0H6; -.
DR   STRING; 7955.ENSDARP00000064214; -.
DR   PaxDb; Q6P0H6; -.
DR   Ensembl; ENSDART00000064215; ENSDARP00000064214; ENSDARG00000043732.
DR   GeneID; 325592; -.
DR   KEGG; dre:325592; -.
DR   CTD; 51138; -.
DR   ZFIN; ZDB-GENE-030131-4317; cops4.
DR   eggNOG; KOG1497; Eukaryota.
DR   GeneTree; ENSGT00940000153510; -.
DR   HOGENOM; CLU_028132_1_0_1; -.
DR   InParanoid; Q6P0H6; -.
DR   OMA; KNIMHTV; -.
DR   OrthoDB; 866823at2759; -.
DR   PhylomeDB; Q6P0H6; -.
DR   TreeFam; TF101147; -.
DR   Reactome; R-DRE-5696394; DNA Damage Recognition in GG-NER.
DR   Reactome; R-DRE-6781823; Formation of TC-NER Pre-Incision Complex.
DR   Reactome; R-DRE-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR   Reactome; R-DRE-8951664; Neddylation.
DR   Reactome; R-DRE-9013422; RHOBTB1 GTPase cycle.
DR   PRO; PR:Q6P0H6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 10.
DR   Bgee; ENSDARG00000043732; Expressed in testis and 28 other tissues.
DR   ExpressionAtlas; Q6P0H6; baseline.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0008180; C:COP9 signalosome; IBA:GO_Central.
DR   GO; GO:0008021; C:synaptic vesicle; IEA:UniProtKB-SubCell.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR037754; CSN4.
DR   InterPro; IPR041406; CSN4_HTH.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR040134; PSMD12/CSN4.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10855; PTHR10855; 1.
DR   PANTHER; PTHR10855:SF2; PTHR10855:SF2; 1.
DR   Pfam; PF18420; CSN4_RPN5_eIF3a; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoplasmic vesicle; Nucleus; Reference proteome; Signalosome;
KW   Synapse.
FT   CHAIN           1..406
FT                   /note="COP9 signalosome complex subunit 4"
FT                   /id="PRO_0000120990"
FT   DOMAIN          197..366
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   CONFLICT        298
FT                   /note="S -> SS (in Ref. 1; AAH56527)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   406 AA;  46346 MW;  2074D77CE2CF0A2A CRC64;
     MASGVRQELA QLMNSSGSHK DLAGKYRQIL EKALQFTDAE QLEALKAFVE AMVNENVSLV
     ISRQLLTDFC AHLPNLPDDI AKVVCHFTLE KIQPRVISFE EQVASIRQHL ATIYEKQEDW
     RNAAQVLVGI PLETGQKQYN VDYKLDTYLK IARLYLEDDD PVQAEAYINR ASLLQNESTN
     EQLQIHYKVC YARVLDYRRK FIEAAQRYNE LSYKSIVHET ERLEALKHAL HCTILASAGQ
     QRSRMLATLF KDERCQQLAA YGILEKMYLD RIIRGNQLQE FAAMLMPHQK ATTADGSSIL
     DRAVIEHNLL SASKLYNNIT FEELGALLEI PPAKAEKIAS QMITEGRMNG FIDQIDGIVH
     FETREPLPTW DKQIQSLCFQ VNNLLEKISQ TAPEWTAQAI EAQMSQ