ID   CSN4_DICDI              Reviewed;         393 AA.
AC   Q54B82; Q2PQ75;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=COP9 signalosome complex subunit 4;
DE            Short=Signalosome subunit 4;
GN   Name=csn4; ORFNames=DDB_G0293844;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=AX3;
RX   PubMed=16781008; DOI=10.1016/j.ejcb.2006.04.006;
RA   Rosel D., Kimmel A.R.;
RT   "The COP9 signalosome regulates cell proliferation of Dictyostelium
RT   discoideum.";
RL   Eur. J. Cell Biol. 85:1023-1034(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC       involved in various cellular and developmental processes. The CSN
CC       complex is an essential regulator of the ubiquitin (Ubl) conjugation
CC       pathway by mediating the deneddylation of the cullin subunits of E3
CC       ligase complexes, leading to modify the Ubl ligase activity.
CC   -!- SUBUNIT: Component of the CSN complex. The holocomplex is comprised of
CC       8 subunits csn1-8. In the complex, it probably interacts directly with
CC       csn1, csn2, csn3, csn4, csn6 and csn8.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSN4 family. {ECO:0000305}.
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DR   EMBL; DQ309432; ABC46696.1; -; mRNA.
DR   EMBL; AAFI02000222; EAL60525.1; -; Genomic_DNA.
DR   RefSeq; XP_628938.1; XM_628936.1.
DR   AlphaFoldDB; Q54B82; -.
DR   SMR; Q54B82; -.
DR   STRING; 44689.DDB0233102; -.
DR   PaxDb; Q54B82; -.
DR   EnsemblProtists; EAL60525; EAL60525; DDB_G0293844.
DR   GeneID; 8629446; -.
DR   KEGG; ddi:DDB_G0293844; -.
DR   dictyBase; DDB_G0293844; csn4.
DR   eggNOG; KOG1497; Eukaryota.
DR   HOGENOM; CLU_028132_1_0_1; -.
DR   InParanoid; Q54B82; -.
DR   OMA; KNIMHTV; -.
DR   PhylomeDB; Q54B82; -.
DR   Reactome; R-DDI-5696394; DNA Damage Recognition in GG-NER.
DR   Reactome; R-DDI-6781823; Formation of TC-NER Pre-Incision Complex.
DR   Reactome; R-DDI-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR   Reactome; R-DDI-8951664; Neddylation.
DR   Reactome; R-DDI-9013422; RHOBTB1 GTPase cycle.
DR   PRO; PR:Q54B82; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0008180; C:COP9 signalosome; IPI:dictyBase.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR037754; CSN4.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR040134; PSMD12/CSN4.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10855; PTHR10855; 1.
DR   PANTHER; PTHR10855:SF2; PTHR10855:SF2; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..393
FT                   /note="COP9 signalosome complex subunit 4"
FT                   /id="PRO_0000327765"
FT   DOMAIN          197..362
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   393 AA;  45383 MW;  515CD343FD8D5339 CRC64;
     MDVNNLKQIL EETSALSDHK TKTEKYKSIL QQLVESKQVA PLKVFITHLT DESTPLVISR
     TILLSFTSSH KTLPEDIQME LGIFVLDRIQ NRVVAFEEQV SEIRYNLAKL YERQENWRES
     ARCLIAIPLD SSQRVISPEY KVKIYVKIAR LFLEEEESGQ AETYINRASD SLHLVKNQKL
     ILAHKTCFAR IMDYKRMFLK ASLRYYDLSQ CLPKDTERMH ALSCAIVCAI LDKAGPQRSR
     TLATLYKDER SQQLGVYTFL EKMFLERILK KTEVKKFAEQ LKPHQMALLS DGNTVLDRAV
     IEHNLLSASK LYNNITFDEL GSLLEIQAEK AEKVASKMVC EERLIGSIDQ IERLIQFENV
     GDSLTQWDKK IEGLCIHMNN IIESISKYPE FIV