ID   CSN4_EMENI              Reviewed;         408 AA.
AC   Q9C467; C8VMX6; Q5BD41;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 2.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=COP9 signalosome complex subunit 4;
DE            Short=Signalosome subunit 4;
GN   Name=csnD; Synonyms=csn4; ORFNames=AN1539;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, IDENTIFICATION IN THE CSN
RP   COMPLEX, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=17470786; DOI=10.1073/pnas.0702108104;
RA   Busch S., Schwier E.U., Nahlik K., Bayram O., Helmstaedt K., Draht O.W.,
RA   Krappmann S., Valerius O., Lipscomb W.N., Braus G.H.;
RT   "An eight-subunit COP9 signalosome with an intact JAMM motif is required
RT   for fungal fruit body formation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8089-8094(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- FUNCTION: Component of the COP9 signalosome (CSN) complex that acts as
CC       an regulator of the ubiquitin (Ubl) conjugation pathway by mediating
CC       the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-
CC       protein ligase complexes (By similarity). The CSN complex seems to link
CC       protein degradation to sexual development. Required for fruit body
CC       formation. {ECO:0000250, ECO:0000269|PubMed:17470786}.
CC   -!- SUBUNIT: Component of the COP9 signalosome (CSN) complex.
CC       {ECO:0000269|PubMed:17470786}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSN4 family. {ECO:0000305}.
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DR   EMBL; AF236662; AAK14055.2; -; Genomic_DNA.
DR   EMBL; AACD01000025; EAA64246.1; -; Genomic_DNA.
DR   EMBL; BN001307; CBF85069.1; -; Genomic_DNA.
DR   RefSeq; XP_659143.1; XM_654051.1.
DR   AlphaFoldDB; Q9C467; -.
DR   SMR; Q9C467; -.
DR   DIP; DIP-60928N; -.
DR   IntAct; Q9C467; 4.
DR   STRING; 162425.CADANIAP00008166; -.
DR   PRIDE; Q9C467; -.
DR   EnsemblFungi; CBF85069; CBF85069; ANIA_01539.
DR   EnsemblFungi; EAA64246; EAA64246; AN1539.2.
DR   GeneID; 2875265; -.
DR   KEGG; ani:AN1539.2; -.
DR   eggNOG; KOG1497; Eukaryota.
DR   HOGENOM; CLU_028132_1_1_1; -.
DR   InParanoid; Q9C467; -.
DR   OMA; KNIMHTV; -.
DR   OrthoDB; 866823at2759; -.
DR   Proteomes; UP000000560; Chromosome VII.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0008180; C:COP9 signalosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR037754; CSN4.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR040134; PSMD12/CSN4.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10855; PTHR10855; 1.
DR   PANTHER; PTHR10855:SF2; PTHR10855:SF2; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..408
FT                   /note="COP9 signalosome complex subunit 4"
FT                   /id="PRO_0000314744"
FT   DOMAIN          194..374
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   408 AA;  44876 MW;  AB38FCBC6DE4ED99 CRC64;
     MPSQKIISAL AEIESSASPQ NKLQLYNDLL SETVSASPEP QLADDLIYYL DSVLSEDLSI
     VAARPILDSF IYTLRKLSSE TQIKVAQHAV NLLQSRSASV EEQDAQIREI LADAYEAEEE
     YIAAARALQG IHIDSSQRLV SDSAKVKLWI RIVRLYLEED DTTSAEAFLN RIKNLPSKIE
     DHELKLHFRL SQARIQDARR RFLDASQEYF AVSLAAGVDE SDRLQALAAA IRCAVLAPAG
     PQRSRTLATL YKDDRATSVE EFGILEKMFL DRLLTPEEVS AFAQRLAPHQ LAQTADGTTV
     LDKAVVEHNL VAASKLYENI KTDALGAILG LQASGDLTAG EKAEAYAARM VEQGRLSGSI
     DQIDGIIYFE SNTTATGRHI RQWDAGVQGL SEGVERVATN IAEGHLVR