ID   CSN4_NEUCR              Reviewed;         440 AA.
AC   Q7S0P8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=COP9 signalosome complex subunit 4;
DE            Short=Signalosome subunit 4;
GN   Name=csn-4; ORFNames=NCU07361;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY,
RP   IDENTIFICATION IN THE COP9 SIGNALOSOME COMPLEX, AND FUNCTION OF THE COP9
RP   SIGNALOSOME COMPLEX.
RX   PubMed=15961524; DOI=10.1101/gad.1322205;
RA   He Q., Cheng P., He Q., Liu Y.;
RT   "The COP9 signalosome regulates the Neurospora circadian clock by
RT   controlling the stability of the SCFFWD-1 complex.";
RL   Genes Dev. 19:1518-1531(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Component of the COP9 signalosome (CSN) complex that acts as
CC       an regulator of the ubiquitin (Ubl) conjugation pathway by mediating
CC       the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-
CC       protein ligase complexes (By similarity). The CSN complex is involved
CC       in the regulation of the circadian clock through its control of the
CC       stability of the SCF(FWD1) complex. {ECO:0000250,
CC       ECO:0000269|PubMed:15961524}.
CC   -!- SUBUNIT: Component of the COP9 signalosome (CSN) complex.
CC       {ECO:0000269|PubMed:15961524}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSN4 family. {ECO:0000305}.
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DR   EMBL; DQ242512; ABB36582.1; -; mRNA.
DR   EMBL; CM002236; EAA28898.1; -; Genomic_DNA.
DR   RefSeq; XP_958134.1; XM_953041.2.
DR   AlphaFoldDB; Q7S0P8; -.
DR   SMR; Q7S0P8; -.
DR   STRING; 5141.EFNCRP00000007346; -.
DR   EnsemblFungi; EAA28898; EAA28898; NCU07361.
DR   GeneID; 3874281; -.
DR   KEGG; ncr:NCU07361; -.
DR   VEuPathDB; FungiDB:NCU07361; -.
DR   HOGENOM; CLU_028132_1_0_1; -.
DR   InParanoid; Q7S0P8; -.
DR   OMA; KNIMHTV; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0008180; C:COP9 signalosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR037754; CSN4.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR040134; PSMD12/CSN4.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10855; PTHR10855; 1.
DR   PANTHER; PTHR10855:SF2; PTHR10855:SF2; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..440
FT                   /note="COP9 signalosome complex subunit 4"
FT                   /id="PRO_0000314745"
FT   DOMAIN          216..386
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   440 AA;  47926 MW;  A27C89C850172C41 CRC64;
     MVSSEVRDLL AQVPNWSQAD RPAAFRTIIT TITSSPDPSH FAADLKAVTD AIFLESLGVV
     ATRALVIDLI DALKSLASGG PSADSINSTT SSIWLDVGKA IQQHIQSNPT LATSLVDQTA
     TIYEELLAAA HESQNSFTDA AKTLAAIPLD SSQRRVTDKY KADLWIRIIR NYLEDDDATS
     AETYLNKLKN IIHNVADDNP VLNLHFKLSA ARIQDSNRQF LAASQSYYEI SLSPAIAEEE
     RLHTLSMAIK CAVLAPAGPP RSRVLARLYK DERSASLEEF GILEKMFLDR LLARAEVEKF
     AQGLAPHQLA TTSDGSTVLA KAMVEHNLLA VSRLYRNIGF DALGSWLGLD SGNKAEEITA
     RMIEQGRLAG SIDQIDRIIY FESGLEASGE KGSGRAEVPV GKEMRRQDGM VQALAEDLER
     ITDDLLVEFP QLVPAGVPGN