CSN4_SCHPO
ID CSN4_SCHPO Reviewed; 377 AA.
AC O13895;
DT 16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 118.
DE RecName: Full=COP9 signalosome complex subunit 4;
DE Short=CSN complex subunit 4;
DE Short=SGN4;
GN Name=csn4; ORFNames=SPAC22A12.03c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBUNIT, AND SUBCELLULAR LOCATION.
RX PubMed=11854407; DOI=10.1091/mbc.01-10-0521;
RA Mundt K.E., Liu C., Carr A.M.;
RT "Deletion mutants in COP9/signalosome subunits in fission yeast
RT Schizosaccharomyces pombe display distinct phenotypes.";
RL Mol. Biol. Cell 13:493-502(2002).
CC -!- FUNCTION: Component of the COP9 signalosome (CSN) complex that acts as
CC an regulator of the ubiquitin (Ubl) conjugation pathway by mediating
CC the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-
CC protein ligase complexes. {ECO:0000250}.
CC -!- SUBUNIT: Component of the COP9 signalosome (CSN) complex composed of at
CC least csn1, csn2, csn4 and csn5 subunits.
CC {ECO:0000269|PubMed:11854407}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11854407}. Nucleus
CC {ECO:0000269|PubMed:11854407}.
CC -!- SIMILARITY: Belongs to the CSN4 family. {ECO:0000305}.
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DR EMBL; CU329670; CAB16573.1; -; Genomic_DNA.
DR PIR; T38143; T38143.
DR RefSeq; NP_593233.1; NM_001018630.2.
DR AlphaFoldDB; O13895; -.
DR SMR; O13895; -.
DR BioGRID; 278018; 13.
DR IntAct; O13895; 1.
DR STRING; 4896.SPAC22A12.03c.1; -.
DR MaxQB; O13895; -.
DR PaxDb; O13895; -.
DR EnsemblFungi; SPAC22A12.03c.1; SPAC22A12.03c.1:pep; SPAC22A12.03c.
DR GeneID; 2541517; -.
DR KEGG; spo:SPAC22A12.03c; -.
DR PomBase; SPAC22A12.03c; csn4.
DR VEuPathDB; FungiDB:SPAC22A12.03c; -.
DR eggNOG; KOG1497; Eukaryota.
DR HOGENOM; CLU_750396_0_0_1; -.
DR InParanoid; O13895; -.
DR OMA; KNIMHTV; -.
DR PhylomeDB; O13895; -.
DR Reactome; R-SPO-6781823; Formation of TC-NER Pre-Incision Complex.
DR PRO; PR:O13895; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0008180; C:COP9 signalosome; ISO:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0000338; P:protein deneddylation; IMP:PomBase.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR037754; CSN4.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR040134; PSMD12/CSN4.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10855; PTHR10855; 1.
DR PANTHER; PTHR10855:SF2; PTHR10855:SF2; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50250; PCI; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT CHAIN 1..377
FT /note="COP9 signalosome complex subunit 4"
FT /id="PRO_0000120995"
FT DOMAIN 190..356
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ SEQUENCE 377 AA; 43063 MW; 49087FF0DAACC53E CRC64;
MEEVVHYFLE GNMPVAQFRE ALALHYTNEK ELFEQAKRCL NICCGSNNFA KRNDVLFSLL
DVAVSISSLE LRKELISELY VPVQSLEEAP SEYLVSCCLQ LATIYEAEQN FELLCSSLEA
VEKHGHFEND LEQLLLLRIR LGDAYLKLGK AEKAILTVRT SIPLAFKVSN DQLLMELQLC
NARALDETGQ FLEAAKCYYR VLQYKVPGNE LIYRENLCSV AQCLLLAIPS PIVLQFLQEI
SLQPSVREIP FYSLVEKYLK RKFIGKEDGA FLLPFLLPHQ VIHMNRLIED GRHFLETNIL
FLSEFFEVSS TSILAKHFKL SEEQVDTVVA DMVIQERLNA SIDQCEGYIT FLPEYGKANN
LPNYVNKIAT VLQHYGS
