CSN6A_BRAOL
ID CSN6A_BRAOL Reviewed; 66 AA.
AC P68356;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 25-MAY-2022, entry version 37.
DE RecName: Full=COP9 signalosome complex subunit 6a;
DE Short=Signalosome subunit 6a;
DE Flags: Fragments;
GN Name=CSN6A;
OS Brassica oleracea (Wild cabbage).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica.
OX NCBI_TaxID=3712;
RN [1]
RP PROTEIN SEQUENCE OF 1-35 AND 52-66.
RX PubMed=11701877; DOI=10.2307/3871583;
RA Peng Z., Serino G., Deng X.-W.;
RT "Molecular characterization of subunit 6 of the COP9 signalosome and its
RT role in multifaceted developmental processes in Arabidopsis.";
RL Plant Cell 13:2393-2407(2001).
RN [2]
RP PROTEIN SEQUENCE OF 36-51, AND COMPONENT OF THE CSN COMPLEX WITH CSN1;
RP CSN2; CSN3; CSN4; CSN5; CSN7 AND CSN8.
RX PubMed=10521526; DOI=10.2307/3871091;
RA Serino G., Tsuge T., Kwok S., Matsui M., Wei N., Deng X.-W.;
RT "Arabidopsis cop8 and fus4 mutations define the same gene that encodes
RT subunit 4 of the COP9 signalosome.";
RL Plant Cell 11:1967-1980(1999).
CC -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC involved in various cellular and developmental processes such as
CC photomorphogenesis and auxin and jasmonate responses. The CSN complex
CC is an essential regulator of the ubiquitin (Ubl) conjugation pathway by
CC mediating the deneddylation of the cullin subunits of SCF-type E3
CC ligase complexes, leading to decrease the Ubl ligase activity of SCF.
CC It is involved in repression of photomorphogenesis in darkness by
CC regulating the activity of COP1-containing Ubl ligase complexes (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the CSN complex, probably composed of CSN1, CSN2,
CC CSN3, CSN4, CSN5 (CSN5A or CSN5B), CSN6 (CSN6A or CSN6B), CSN7 and
CC CSN8.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC -!- MISCELLANEOUS: Although strongly related to metalloprotease proteins,
CC it lacks the JAMM motif that probably constitutes the catalytic center.
CC Its function as protease is therefore unsure.
CC -!- SIMILARITY: Belongs to the peptidase M67A family. CSN6 subfamily.
CC {ECO:0000305}.
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DR AlphaFoldDB; P68356; -.
DR SMR; P68356; -.
DR GO; GO:0008180; C:COP9 signalosome; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009585; P:red, far-red light phototransduction; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Cytoplasm; Developmental protein; Direct protein sequencing; Nucleus;
KW Phytochrome signaling pathway; Signalosome.
FT CHAIN <1..>66
FT /note="COP9 signalosome complex subunit 6a"
FT /id="PRO_0000194866"
FT NON_CONS 35..36
FT /evidence="ECO:0000305"
FT NON_CONS 51..52
FT /evidence="ECO:0000305"
FT NON_TER 1
FT NON_TER 66
SQ SEQUENCE 66 AA; 7892 MW; F4E72E49445BA7E0 CRC64;
KGRTVEIFNS FELLLDPTTQ TLDRSFLEKK QELYKKMLNS RIRVLHQYLA AKFNTAYERN
TRRGGR