CSN6_DICDI
ID CSN6_DICDI Reviewed; 309 AA.
AC Q54C92; Q2PQ73;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=COP9 signalosome complex subunit 6;
DE Short=Signalosome subunit 6;
GN Name=csn6; ORFNames=DDB_G0293180;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION IN THE CSN COMPLEX, AND
RP SUBCELLULAR LOCATION.
RX PubMed=16781008; DOI=10.1016/j.ejcb.2006.04.006;
RA Rosel D., Kimmel A.R.;
RT "The COP9 signalosome regulates cell proliferation of Dictyostelium
RT discoideum.";
RL Eur. J. Cell Biol. 85:1023-1034(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=AX2;
RX PubMed=16926386; DOI=10.1074/mcp.m600113-mcp200;
RA Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M.,
RA Soldati T.;
RT "Proteomics fingerprinting of phagosome maturation and evidence for the
RT role of a Galpha during uptake.";
RL Mol. Cell. Proteomics 5:2228-2243(2006).
CC -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC involved in various cellular and developmental processes. The CSN
CC complex is an essential regulator of the ubiquitin (Ubl) conjugation
CC pathway by mediating the deneddylation of the cullin subunits of E3
CC ligase complexes, leading to modify the Ubl ligase activity.
CC -!- SUBUNIT: Component of the CSN complex. The holocomplex is comprised of
CC 8 subunits csn1-8. In the complex, it probably interacts directly with
CC csn2, csn5 and csn7. {ECO:0000269|PubMed:16781008}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:16781008}.
CC -!- MISCELLANEOUS: Although strongly related to metalloprotease proteins,
CC it lacks the JAMM motif that probably constitutes the catalytic center.
CC Its function as protease is therefore unsure (By similarity).
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the peptidase M67A family. CSN6 subfamily.
CC {ECO:0000305}.
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DR EMBL; DQ309434; ABC46698.1; -; mRNA.
DR EMBL; AAFI02000199; EAL60942.1; -; Genomic_DNA.
DR RefSeq; XP_629327.1; XM_629325.1.
DR AlphaFoldDB; Q54C92; -.
DR SMR; Q54C92; -.
DR STRING; 44689.DDB0233105; -.
DR PaxDb; Q54C92; -.
DR EnsemblProtists; EAL60942; EAL60942; DDB_G0293180.
DR GeneID; 8629051; -.
DR KEGG; ddi:DDB_G0293180; -.
DR dictyBase; DDB_G0293180; csn6.
DR eggNOG; KOG3050; Eukaryota.
DR HOGENOM; CLU_027018_1_2_1; -.
DR InParanoid; Q54C92; -.
DR OMA; DLVGWYT; -.
DR PhylomeDB; Q54C92; -.
DR Reactome; R-DDI-5696394; DNA Damage Recognition in GG-NER.
DR Reactome; R-DDI-6781823; Formation of TC-NER Pre-Incision Complex.
DR Reactome; R-DDI-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR Reactome; R-DDI-8951664; Neddylation.
DR PRO; PR:Q54C92; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0008180; C:COP9 signalosome; IPI:dictyBase.
DR GO; GO:0045335; C:phagocytic vesicle; HDA:dictyBase.
DR GO; GO:0070122; F:isopeptidase activity; IEA:InterPro.
DR GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR GO; GO:0000338; P:protein deneddylation; IEA:InterPro.
DR CDD; cd08063; MPN_CSN6; 1.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR033859; MPN_CSN6.
DR InterPro; IPR024969; Rpn11/EIF3F_C.
DR Pfam; PF01398; JAB; 1.
DR Pfam; PF13012; MitMem_reg; 1.
DR SMART; SM00232; JAB_MPN; 1.
DR PROSITE; PS50249; MPN; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoplasmic vesicle; Nucleus; Reference proteome; Signalosome.
FT CHAIN 1..309
FT /note="COP9 signalosome complex subunit 6"
FT /id="PRO_0000327769"
FT DOMAIN 28..161
FT /note="MPN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ SEQUENCE 309 AA; 35107 MW; 77193D7823CBF176 CRC64;
MTDTTTTTTT DANKLVLEKS ANSSGLEVDL HPLVLINISD HFTRTKVQSN YQDNCRVIGV
ILGVQNGRNV EICNSFEMVY ATVDKQLVLD IEYLRKKYEQ LFPLYDLLGW YSTGSQVSKD
DILLHKQISE HNESPLYLML DTDSPKSKDL PVIIYESELH IVNDEPTTIF VKTPYKIQTG
EAERIGVNHI AKVTPSGSEG SGLTSHLFTM HNAISMLNIR VKALSDYLQA VKEKRLPYEQ
NILRKASSLC NQLPTIDTHD FKKSYLQEYN DVLLVTYLAS ITKTSASLND TIDKYLVSNE
KQSKRRFYQ
