ID   CSN6_EMENI              Reviewed;         386 AA.
AC   Q5BB47; C8VMS5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 2.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=COP9 signalosome complex subunit 6;
DE            Short=Signalosome subunit 6;
GN   Name=csnF; Synonyms=csn6; ORFNames=AN2233;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
RN   [3]
RP   IDENTIFICATION IN THE CSN COMPLEX, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=17470786; DOI=10.1073/pnas.0702108104;
RA   Busch S., Schwier E.U., Nahlik K., Bayram O., Helmstaedt K., Draht O.W.,
RA   Krappmann S., Valerius O., Lipscomb W.N., Braus G.H.;
RT   "An eight-subunit COP9 signalosome with an intact JAMM motif is required
RT   for fungal fruit body formation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8089-8094(2007).
CC   -!- FUNCTION: Component of the COP9 signalosome (CSN) complex that acts as
CC       an regulator of the ubiquitin (Ubl) conjugation pathway by mediating
CC       the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-
CC       protein ligase complexes (By similarity). The CSN complex seems to link
CC       protein degradation to sexual development. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the COP9 signalosome (CSN) complex.
CC       {ECO:0000269|PubMed:17470786}.
CC   -!- INTERACTION:
CC       Q5BB47; Q5BBF1: rri1; NbExp=3; IntAct=EBI-15634741, EBI-15634720;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase M67A family. CSN6 subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAA63918.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AACD01000036; EAA63918.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BN001307; CBF86434.1; -; Genomic_DNA.
DR   RefSeq; XP_659837.1; XM_654745.1.
DR   AlphaFoldDB; Q5BB47; -.
DR   SMR; Q5BB47; -.
DR   DIP; DIP-60930N; -.
DR   IntAct; Q5BB47; 2.
DR   STRING; 162425.CADANIAP00008919; -.
DR   EnsemblFungi; CBF86434; CBF86434; ANIA_02233.
DR   EnsemblFungi; EAA63918; EAA63918; AN2233.2.
DR   GeneID; 2875096; -.
DR   KEGG; ani:AN2233.2; -.
DR   VEuPathDB; FungiDB:AN2233; -.
DR   eggNOG; KOG3050; Eukaryota.
DR   HOGENOM; CLU_027018_2_0_1; -.
DR   InParanoid; Q5BB47; -.
DR   OMA; DLVGWYT; -.
DR   OrthoDB; 1455324at2759; -.
DR   Proteomes; UP000000560; Chromosome VII.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0008180; C:COP9 signalosome; IDA:AspGD.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070122; F:isopeptidase activity; IEA:InterPro.
DR   GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR   GO; GO:0070791; P:cleistothecium development; IPI:AspGD.
DR   GO; GO:0000338; P:protein deneddylation; IEA:InterPro.
DR   CDD; cd08063; MPN_CSN6; 1.
DR   InterPro; IPR000555; JAMM/MPN+_dom.
DR   InterPro; IPR037518; MPN.
DR   InterPro; IPR033859; MPN_CSN6.
DR   InterPro; IPR024969; Rpn11/EIF3F_C.
DR   Pfam; PF01398; JAB; 1.
DR   Pfam; PF13012; MitMem_reg; 1.
DR   PROSITE; PS50249; MPN; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..386
FT                   /note="COP9 signalosome complex subunit 6"
FT                   /id="PRO_0000314734"
FT   DOMAIN          20..164
FT                   /note="MPN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT   REGION          218..241
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   386 AA;  42088 MW;  5A7F7DF7AF369808 CRC64;
     MPDEAISILS QKSSDSGLHI QLHPLALLTI SDHITRHAAR SQQGPIVGGL LGQHNGREIT
     VEHGFECVVE IGPNGEAQLP NEWFVDRVKQ FKDVHKVPAL DLIGWWSTAP PSGPTTAHLP
     IHRQILQNHN ESAVFLTFHP SQVQGASQSQ GKLPLTIYES VYEGESVTEN GKAMQVDGEE
     QLLNIRFREL PYTIETGEAE MIGIDTVART ARNAAATETS TVAAPSSQID SDKQEQQPAN
     TDLLSPEEEE LIASLNTRLN AIRTLESRIS LIKSYLSSIS PSSEEGQKDS ATKPDHTILR
     DINSLLSNLS LLTPHEQSAF SAETLAQNND VSLVALLGQL SQSVNGMREV GKRTAIVNSV
     RRNRKQLGAQ SRYEDDILGR DGVALG