CSN6_MOUSE
ID CSN6_MOUSE Reviewed; 324 AA.
AC O88545;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=COP9 signalosome complex subunit 6;
DE Short=SGN6;
DE Short=Signalosome subunit 6;
DE AltName: Full=JAB1-containing signalosome subunit 6;
GN Name=Cops6; Synonyms=Csn6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND IDENTIFICATION IN THE CSN COMPLEX.
RC STRAIN=BALB/cJ;
RX PubMed=9707402; DOI=10.1016/s0960-9822(07)00372-7;
RA Wei N., Tsuge T., Serino G., Dohmae N., Takio K., Matsui M., Deng X.-W.;
RT "The COP9 complex is conserved between plants and mammals and is related to
RT the 26S proteasome regulatory complex.";
RL Curr. Biol. 8:919-922(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC involved in various cellular and developmental processes (By
CC similarity). The CSN complex is an essential regulator of the ubiquitin
CC (Ubl) conjugation pathway by mediating the deneddylation of the cullin
CC subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl
CC ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By
CC similarity). The complex is also involved in phosphorylation of
CC p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via
CC its association with CK2 and PKD kinases (By similarity). CSN-dependent
CC phosphorylation of TP53 and JUN promotes and protects degradation by
CC the Ubl system, respectively (By similarity). Has some glucocorticoid
CC receptor-responsive activity (By similarity). Stabilizes COP1 through
CC reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate,
CC hence regulates the ubiquitination of COP1 targets, including SFN (By
CC similarity). {ECO:0000250|UniProtKB:Q7L5N1}.
CC -!- SUBUNIT: Component of the CSN complex, composed of COPS1/GPS1, COPS2,
CC COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9
CC (PubMed:9707402). In the complex, it probably interacts directly with
CC COPS2, COPS4, COPS5, COPS7 (COPS7A or COPS7B) and COPS9 (By
CC similarity). Interacts with the translation initiation factor EIF3S6
CC (By similarity). Interacts weakly with RBX1 (By similarity). Directly
CC interacts with COP1 and 14-3-3 protein sigma/SFN (By similarity).
CC Interacts with ERCC6 (By similarity). {ECO:0000250|UniProtKB:Q7L5N1,
CC ECO:0000269|PubMed:9707402}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q7L5N1}. Nucleus
CC {ECO:0000250|UniProtKB:Q7L5N1}.
CC -!- SIMILARITY: Belongs to the peptidase M67A family. CSN6 subfamily.
CC {ECO:0000305}.
CC -!- CAUTION: Although related to the peptidase M67A family, it lacks the
CC JAMM motif that probably constitutes the catalytic center and therefore
CC it probably does not have a protease activity. {ECO:0000305}.
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DR EMBL; AF071315; AAC33902.1; -; mRNA.
DR EMBL; BC004664; AAH04664.1; -; mRNA.
DR EMBL; BC014286; AAH14286.1; -; mRNA.
DR CCDS; CCDS19792.1; -.
DR RefSeq; NP_036132.1; NM_012002.3.
DR AlphaFoldDB; O88545; -.
DR SMR; O88545; -.
DR BioGRID; 205044; 50.
DR CORUM; O88545; -.
DR IntAct; O88545; 1.
DR MINT; O88545; -.
DR STRING; 10090.ENSMUSP00000019638; -.
DR MEROPS; M67.972; -.
DR iPTMnet; O88545; -.
DR PhosphoSitePlus; O88545; -.
DR EPD; O88545; -.
DR jPOST; O88545; -.
DR PaxDb; O88545; -.
DR PRIDE; O88545; -.
DR ProteomicsDB; 284139; -.
DR Antibodypedia; 30510; 218 antibodies from 25 providers.
DR DNASU; 26893; -.
DR Ensembl; ENSMUST00000019638; ENSMUSP00000019638; ENSMUSG00000019494.
DR GeneID; 26893; -.
DR KEGG; mmu:26893; -.
DR UCSC; uc009aer.1; mouse.
DR CTD; 10980; -.
DR MGI; MGI:1349439; Cops6.
DR VEuPathDB; HostDB:ENSMUSG00000019494; -.
DR eggNOG; KOG3050; Eukaryota.
DR GeneTree; ENSGT00950000183073; -.
DR InParanoid; O88545; -.
DR OMA; DLVGWYT; -.
DR OrthoDB; 1455324at2759; -.
DR PhylomeDB; O88545; -.
DR TreeFam; TF101148; -.
DR Reactome; R-MMU-5696394; DNA Damage Recognition in GG-NER.
DR Reactome; R-MMU-6781823; Formation of TC-NER Pre-Incision Complex.
DR Reactome; R-MMU-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR Reactome; R-MMU-8951664; Neddylation.
DR BioGRID-ORCS; 26893; 29 hits in 73 CRISPR screens.
DR ChiTaRS; Cops6; mouse.
DR PRO; PR:O88545; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; O88545; protein.
DR Bgee; ENSMUSG00000019494; Expressed in embryonic brain and 276 other tissues.
DR ExpressionAtlas; O88545; baseline and differential.
DR Genevisible; O88545; MM.
DR GO; GO:0008180; C:COP9 signalosome; IDA:MGI.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0070122; F:isopeptidase activity; IEA:InterPro.
DR GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR GO; GO:0000338; P:protein deneddylation; ISO:MGI.
DR CDD; cd08063; MPN_CSN6; 1.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR033859; MPN_CSN6.
DR InterPro; IPR024969; Rpn11/EIF3F_C.
DR Pfam; PF01398; JAB; 1.
DR Pfam; PF13012; MitMem_reg; 1.
DR SMART; SM00232; JAB_MPN; 1.
DR PROSITE; PS50249; MPN; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT CHAIN 1..324
FT /note="COP9 signalosome complex subunit 6"
FT /id="PRO_0000194861"
FT DOMAIN 38..171
FT /note="MPN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ SEQUENCE 324 AA; 35880 MW; 8F8B7EC5DF67C721 CRC64;
MAAAAAAGAN GSGGSSGMEV DAAVPSVMAS GVTGSVSVAL HPLVILNISD HWIRMRSQEG
RPMQVIGALI GKQEGRNIEV MNSFELLSHT VEEKIIIDKE YYYTKEEQFK QVFKELEFLG
WYTTGGPPDP SDIHVHKQVC EIIESPLFLK LNPMTKHTDL PVSVFESVID IINGEATMLF
AELTYTLATE EAERIGVDHV ARMTATGSGE NSTVAEHLIA QHSAIKMLHS RVKLILEYVK
ASEAGEVPFN HEILREAYAL CHCLPVLSTD KFKTDFYDQC NDVGLMAYLG TITKTCNTMN
QFVNKFNVLY DRQGIGRRMR GLFF
