ID   CSN6_XENLA              Reviewed;         318 AA.
AC   Q6NUC2;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=COP9 signalosome complex subunit 6;
DE            Short=Signalosome subunit 6;
GN   Name=cops6; Synonyms=csn6;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC       involved in various cellular and developmental processes (By
CC       similarity). The CSN complex is an essential regulator of the ubiquitin
CC       (Ubl) conjugation pathway by mediating the deneddylation of the cullin
CC       subunits of E3 ligase complexes, leading to modify the Ubl ligase
CC       activity (By similarity). {ECO:0000250|UniProtKB:Q7L5N1}.
CC   -!- SUBUNIT: Component of the CSN complex, probably composed of cops1,
CC       cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
CC       {ECO:0000250|UniProtKB:Q7L5N1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q7L5N1}. Nucleus
CC       {ECO:0000250|UniProtKB:Q7L5N1}.
CC   -!- SIMILARITY: Belongs to the peptidase M67A family. CSN6 subfamily.
CC       {ECO:0000305}.
CC   -!- CAUTION: Although related to the peptidase M67A family, it lacks the
CC       JAMM motif that probably constitutes the catalytic center and therefore
CC       it probably does not have a protease activity. {ECO:0000305}.
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DR   EMBL; BC068673; AAH68673.1; -; mRNA.
DR   RefSeq; NP_001084619.1; NM_001091150.1.
DR   AlphaFoldDB; Q6NUC2; -.
DR   SMR; Q6NUC2; -.
DR   MaxQB; Q6NUC2; -.
DR   DNASU; 414575; -.
DR   GeneID; 414575; -.
DR   KEGG; xla:414575; -.
DR   CTD; 414575; -.
DR   Xenbase; XB-GENE-947833; cops6.S.
DR   OrthoDB; 1455324at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 414575; Expressed in internal ear and 19 other tissues.
DR   GO; GO:0008180; C:COP9 signalosome; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070122; F:isopeptidase activity; IEA:InterPro.
DR   GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR   GO; GO:0000338; P:protein deneddylation; IEA:InterPro.
DR   CDD; cd08063; MPN_CSN6; 1.
DR   InterPro; IPR000555; JAMM/MPN+_dom.
DR   InterPro; IPR037518; MPN.
DR   InterPro; IPR033859; MPN_CSN6.
DR   InterPro; IPR024969; Rpn11/EIF3F_C.
DR   Pfam; PF01398; JAB; 1.
DR   Pfam; PF13012; MitMem_reg; 1.
DR   SMART; SM00232; JAB_MPN; 1.
DR   PROSITE; PS50249; MPN; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..318
FT                   /note="COP9 signalosome complex subunit 6"
FT                   /id="PRO_0000194862"
FT   DOMAIN          32..165
FT                   /note="MPN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ   SEQUENCE   318 AA;  35537 MW;  2888E284C187CBF1 CRC64;
     MAAAASNGNG MEVDVAALPS VMAQGVTGSV TVALHPLVIL NISDHWIRMR SQEGRPMQVI
     GALIGKQEGR NIEVMNSFEL LSQINDEKIT INKEYYYTKE EQFKQVFKDM EFLGWYTTGG
     TPDPSDIHVH KQVCEIIESP LFLKLNPMTK HTDLPVSVYE SVIDIVNGEA TMLLAELSYT
     LATEEAERIG VDHVARMTAT GSGENSTVAE HLIAQHSAIK MLHSRVRLIL EYVRAAEGGE
     VPFNHEILRE ASALCHCLPV LSTDKFKTDF YDQCNDVGLM SYLGTITKTC NTMNQFVNKF
     NILYDRQGIG RRMRGLFF