ID   CSN6_XENTR              Reviewed;         319 AA.
AC   Q07G98;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=COP9 signalosome complex subunit 6;
DE            Short=Signalosome subunit 6;
GN   Name=cops6; Synonyms=csn6; ORFNames=TNeu117c08.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC       involved in various cellular and developmental processes (By
CC       similarity). The CSN complex is an essential regulator of the ubiquitin
CC       (Ubl) conjugation pathway by mediating the deneddylation of the cullin
CC       subunits of E3 ligase complexes, leading to modify the Ubl ligase
CC       activity (By similarity). {ECO:0000250|UniProtKB:Q7L5N1}.
CC   -!- SUBUNIT: Component of the CSN complex, probably composed of cops1,
CC       cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
CC       {ECO:0000250|UniProtKB:Q7L5N1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q7L5N1}. Nucleus
CC       {ECO:0000250|UniProtKB:Q7L5N1}.
CC   -!- SIMILARITY: Belongs to the peptidase M67A family. CSN6 subfamily.
CC       {ECO:0000305}.
CC   -!- CAUTION: Although related to the peptidase M67A family, it lacks the
CC       JAMM motif that probably constitutes the catalytic center and therefore
CC       it probably does not have a protease activity. {ECO:0000305}.
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DR   EMBL; CR760300; CAL49407.1; -; mRNA.
DR   RefSeq; NP_001265456.1; NM_001278527.1.
DR   AlphaFoldDB; Q07G98; -.
DR   SMR; Q07G98; -.
DR   STRING; 8364.ENSXETP00000050248; -.
DR   PaxDb; Q07G98; -.
DR   DNASU; 448375; -.
DR   GeneID; 448375; -.
DR   KEGG; xtr:448375; -.
DR   CTD; 10980; -.
DR   Xenbase; XB-GENE-947827; cops6.
DR   eggNOG; KOG3050; Eukaryota.
DR   InParanoid; Q07G98; -.
DR   OrthoDB; 1455324at2759; -.
DR   Reactome; R-XTR-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR   Reactome; R-XTR-8951664; Neddylation.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0008180; C:COP9 signalosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070122; F:isopeptidase activity; IEA:InterPro.
DR   GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR   GO; GO:0000338; P:protein deneddylation; IEA:InterPro.
DR   CDD; cd08063; MPN_CSN6; 1.
DR   InterPro; IPR000555; JAMM/MPN+_dom.
DR   InterPro; IPR037518; MPN.
DR   InterPro; IPR033859; MPN_CSN6.
DR   InterPro; IPR024969; Rpn11/EIF3F_C.
DR   Pfam; PF01398; JAB; 1.
DR   Pfam; PF13012; MitMem_reg; 1.
DR   SMART; SM00232; JAB_MPN; 1.
DR   PROSITE; PS50249; MPN; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..319
FT                   /note="COP9 signalosome complex subunit 6"
FT                   /id="PRO_0000331509"
FT   DOMAIN          33..166
FT                   /note="MPN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ   SEQUENCE   319 AA;  35655 MW;  DACF5FBAD7700937 CRC64;
     MAAAAASNGS GMEVDVAAFP TVMAQGVTGS VTVALHPLVI LNISDHWIRM RSQEGRPVQV
     IGALIGKQEG RNIEVMNSFE LLSQINEEKI TINKEYYYTK EEQFKQVFKD MEFLGWYTTG
     GTPDPSDIHV HKQVCEIIES PLFLKLNPMT KHTDLPVSVY ESVIDIVNGE ATMLLAELSY
     TLATEEAERI GVDHVARMTA TGSGENSTVA EHLIAQHSAI KMLHSRVRLI LEYVRAAEAG
     EVPFNHEILR EASALCHCLP VLSTDKFKMD FYDQCNDVGL MSYLGTITKT CNTMNQFVNK
     FNILYDRQGI GRRMRGLFF