ID   CSN7A_NEUCR             Reviewed;         417 AA.
AC   Q7SGS1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=COP9 signalosome complex subunit 7a;
DE            Short=CSN complex subunit 7a;
GN   Name=csn-7a; ORFNames=NCU08342;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE COP9 SIGNALOSOME
RP   COMPLEX, AND FUNCTION OF THE COP9 SIGNALOSOME COMPLEX.
RX   PubMed=15961524; DOI=10.1101/gad.1322205;
RA   He Q., Cheng P., He Q., Liu Y.;
RT   "The COP9 signalosome regulates the Neurospora circadian clock by
RT   controlling the stability of the SCFFWD-1 complex.";
RL   Genes Dev. 19:1518-1531(2005).
CC   -!- FUNCTION: Component of the COP9 signalosome (CSN) complex that acts as
CC       an regulator of the ubiquitin (Ubl) conjugation pathway by mediating
CC       the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-
CC       protein ligase complexes (By similarity). The CSN complex is involved
CC       in the regulation of the circadian clock through its control of the
CC       stability of the SCF(FWD1) complex. {ECO:0000250,
CC       ECO:0000269|PubMed:15961524}.
CC   -!- SUBUNIT: Component of the COP9 signalosome (CSN) complex.
CC       {ECO:0000269|PubMed:15961524}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CM002236; EAA36009.1; -; Genomic_DNA.
DR   RefSeq; XP_965245.1; XM_960152.2.
DR   AlphaFoldDB; Q7SGS1; -.
DR   SMR; Q7SGS1; -.
DR   STRING; 5141.EFNCRP00000006440; -.
DR   PRIDE; Q7SGS1; -.
DR   EnsemblFungi; EAA36009; EAA36009; NCU08342.
DR   GeneID; 3881385; -.
DR   KEGG; ncr:NCU08342; -.
DR   VEuPathDB; FungiDB:NCU08342; -.
DR   HOGENOM; CLU_054426_0_0_1; -.
DR   InParanoid; Q7SGS1; -.
DR   OMA; PANEMVQ; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0008180; C:COP9 signalosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR045237; COPS7/eIF3m.
DR   InterPro; IPR000717; PCI_dom.
DR   PANTHER; PTHR15350; PTHR15350; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..417
FT                   /note="COP9 signalosome complex subunit 7a"
FT                   /id="PRO_0000314737"
FT   DOMAIN          2..179
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          240..417
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        240..260
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        288..309
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        317..334
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        351..366
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        388..402
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        403..417
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   417 AA;  44541 MW;  62BE26AA9C1DC209 CRC64;
     MEQTKALNAL EPFIVLSKSA TSPRAAADLV TRVTSAPNTF IFTELLQTPQ IQSLEYSHEF
     SSYLTLLQIF SHGTYADYIA NASALPALND DQKLKLRQLS LLTLVANDGS NVPLDYDAMQ
     RENNQAQPPN QSYASLTRRL ELSSARELEE LVISAIYAGL IEGQLDPANE MVQINSVAAL
     RDVPARGVNG LLSSLQGWAG RCQATLQELE ATMANLRDEA DRRATEEQEW NNKMSQLLED
     EQKGAVPSSS SSSLPFSWFN NTRGGGGGGD GAGAGGSFRG SGYSRGGGLS QGYRSSQRGS
     HQQHQNQSRQ QQNHHHHHQS NQSGTNSLLT SGGGSYLSFR EGPSAVSPSA AAGLMGSSTS
     FAALGGMETG SGSGSGPLGK RGSSDMDDSE EDIDDDTMDL DDEGDETKRG SKRKLTA