ID   CSN7B_BOVIN             Reviewed;         264 AA.
AC   Q2KI56;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=COP9 signalosome complex subunit 7b;
DE            Short=SGN7b;
DE            Short=Signalosome subunit 7b;
GN   Name=COPS7B;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC       involved in various cellular and developmental processes. The CSN
CC       complex is an essential regulator of the ubiquitin (Ubl) conjugation
CC       pathway by mediating the deneddylation of the cullin subunits of SCF-
CC       type E3 ligase complexes, leading to decrease the Ubl ligase activity
CC       of SCF-type complexes such as SCF, CSA or DDB2. The complex is also
CC       involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA,
CC       ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD
CC       kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and
CC       protects degradation by the Ubl system, respectively (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the CSN complex, composed of COPS1/GPS1, COPS2,
CC       COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9.
CC       In the complex, it probably interacts directly with COPS1, COPS2,
CC       COPS4, COPS5, COPS6 and COPS8. Interacts with EIF3S6.
CC       {ECO:0000250|UniProtKB:Q9H9Q2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC112763; AAI12764.1; -; mRNA.
DR   RefSeq; NP_001040077.1; NM_001046612.1.
DR   RefSeq; XP_005203065.1; XM_005203008.3.
DR   AlphaFoldDB; Q2KI56; -.
DR   SMR; Q2KI56; -.
DR   STRING; 9913.ENSBTAP00000006858; -.
DR   PaxDb; Q2KI56; -.
DR   PRIDE; Q2KI56; -.
DR   Ensembl; ENSBTAT00000006858; ENSBTAP00000006858; ENSBTAG00000005207.
DR   Ensembl; ENSBTAT00000069661; ENSBTAP00000062473; ENSBTAG00000005207.
DR   GeneID; 617995; -.
DR   KEGG; bta:617995; -.
DR   CTD; 64708; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005207; -.
DR   VGNC; VGNC:27605; COPS7B.
DR   eggNOG; KOG3250; Eukaryota.
DR   GeneTree; ENSGT00940000157155; -.
DR   HOGENOM; CLU_054426_1_0_1; -.
DR   InParanoid; Q2KI56; -.
DR   OMA; GTYKQFR; -.
DR   OrthoDB; 1396757at2759; -.
DR   TreeFam; TF101149; -.
DR   Reactome; R-BTA-5696394; DNA Damage Recognition in GG-NER.
DR   Reactome; R-BTA-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000005207; Expressed in choroid plexus and 103 other tissues.
DR   GO; GO:0008180; C:COP9 signalosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0010387; P:COP9 signalosome assembly; IEA:InterPro.
DR   GO; GO:0000338; P:protein deneddylation; IEA:Ensembl.
DR   InterPro; IPR045237; COPS7/eIF3m.
DR   InterPro; IPR041481; CSN7_helixI.
DR   InterPro; IPR027530; Csn7B.
DR   InterPro; IPR000717; PCI_dom.
DR   PANTHER; PTHR15350; PTHR15350; 1.
DR   PANTHER; PTHR15350:SF8; PTHR15350:SF8; 1.
DR   Pfam; PF18392; CSN7a_helixI; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Coiled coil; Cytoplasm; Nucleus; Reference proteome;
KW   Signalosome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H9Q2"
FT   CHAIN           2..264
FT                   /note="COP9 signalosome complex subunit 7b"
FT                   /id="PRO_0000290347"
FT   DOMAIN          2..159
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          223..264
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          194..237
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        236..252
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H9Q2"
SQ   SEQUENCE   264 AA;  29595 MW;  EE7389CEA6D66A07 CRC64;
     MAGEQKPSSN LLEQFILLAK GTSGSALTAL ISQVLEAPGV YVFGELLELA NVQELAEGAN
     AAYLQLLNLF AYGTYPDYIA NKESLPELST AQQNKLKHLT IVSLASRMKC IPYSVLLKDL
     EMRNLRELED LIIEAVYTDI IQGKLDQRNQ LLEVDFCIGR DIRKKDINNI VKTLHEWCDG
     CEAVLLGIEQ QVLRANQYKE NHSRTQQQVE AEVTNIKKTL KATASSSAQE MEQQLAEREC
     PPHAEQRQPT KKMSKVKGLV SSRH