ID   CSN7_DICDI              Reviewed;         259 AA.
AC   Q55BD5; Q2PQ72;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=COP9 signalosome complex subunit 7;
DE            Short=Signalosome subunit 7;
GN   Name=csn7; ORFNames=DDB_G0271282;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND IDENTIFICATION IN THE CSN COMPLEX.
RX   PubMed=16781008; DOI=10.1016/j.ejcb.2006.04.006;
RA   Rosel D., Kimmel A.R.;
RT   "The COP9 signalosome regulates cell proliferation of Dictyostelium
RT   discoideum.";
RL   Eur. J. Cell Biol. 85:1023-1034(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC       involved in various cellular and developmental processes. The CSN
CC       complex is an essential regulator of the ubiquitin (Ubl) conjugation
CC       pathway by mediating the deneddylation of the cullin subunits of E3
CC       ligase complexes, leading to modify the Ubl ligase activity.
CC   -!- SUBUNIT: Component of the CSN complex. The holocomplex is comprised of
CC       8 subunits csn1-8. In the complex, it probably interacts directly with
CC       csn2, csn5, csn6 and csn8. {ECO:0000269|PubMed:16781008}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; DQ309435; ABC46699.1; -; mRNA.
DR   EMBL; AAFI02000006; EAL71771.1; -; Genomic_DNA.
DR   RefSeq; XP_645677.1; XM_640585.1.
DR   AlphaFoldDB; Q55BD5; -.
DR   SMR; Q55BD5; -.
DR   STRING; 44689.DDB0233106; -.
DR   PaxDb; Q55BD5; -.
DR   EnsemblProtists; EAL71771; EAL71771; DDB_G0271282.
DR   GeneID; 8617870; -.
DR   KEGG; ddi:DDB_G0271282; -.
DR   dictyBase; DDB_G0271282; csn7.
DR   eggNOG; KOG3250; Eukaryota.
DR   HOGENOM; CLU_054426_2_1_1; -.
DR   InParanoid; Q55BD5; -.
DR   OMA; GTYKQFR; -.
DR   PhylomeDB; Q55BD5; -.
DR   Reactome; R-DDI-5696394; DNA Damage Recognition in GG-NER.
DR   Reactome; R-DDI-6781823; Formation of TC-NER Pre-Incision Complex.
DR   Reactome; R-DDI-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR   Reactome; R-DDI-8951664; Neddylation.
DR   PRO; PR:Q55BD5; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0008180; C:COP9 signalosome; IPI:dictyBase.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR045237; COPS7/eIF3m.
DR   InterPro; IPR000717; PCI_dom.
DR   PANTHER; PTHR15350; PTHR15350; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..259
FT                   /note="COP9 signalosome complex subunit 7"
FT                   /id="PRO_0000327767"
FT   DOMAIN          1..161
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   259 AA;  29912 MW;  6268ACF994391764 CRC64;
     MTTQQETLTD GNALKQFVVL AKSSKGRAIV SIIEKALNHP SVFVFGELLD MPNVQQLKET
     EFKNYYDLLL IFAYGSFIDY KNKKDSLPQL TPQMITKLKQ LTIVFLSSTS NVIPYSVLQE
     QIEITNVREL EDLIIDSIYQ NIIKGKLDQK NKHLEIDFSI GRDVQPEQLD SMINCLNNWS
     STSQKLLDDI SGLITHSDKV HLQYRKEKEE FESKFEIAKL NTKNDSPAEQ LYYDSMEYSD
     EVRMKKGPKI KGKDYNKRP