ID   CSN7_EMENI              Reviewed;         327 AA.
AC   Q00648; C8V452; Q5B757;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=COP9 signalosome complex subunit 7;
DE            Short=CSN complex subunit 7;
GN   Name=csnG; Synonyms=acoB, csn7; ORFNames=AN3623;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=7551046; DOI=10.1099/13500872-141-8-1821;
RA   Lewis C., Champe S.P.;
RT   "A pre-induction sporulation gene from Aspergillus nidulans.";
RL   Microbiology 141:1821-1828(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
RN   [4]
RP   IDENTIFICATION IN THE CSN COMPLEX, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=17470786; DOI=10.1073/pnas.0702108104;
RA   Busch S., Schwier E.U., Nahlik K., Bayram O., Helmstaedt K., Draht O.W.,
RA   Krappmann S., Valerius O., Lipscomb W.N., Braus G.H.;
RT   "An eight-subunit COP9 signalosome with an intact JAMM motif is required
RT   for fungal fruit body formation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8089-8094(2007).
CC   -!- FUNCTION: Component of the COP9 signalosome (CSN) complex that acts as
CC       an regulator of the ubiquitin (Ubl) conjugation pathway by mediating
CC       the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-
CC       protein ligase complexes (By similarity). The CSN complex seems to link
CC       protein degradation to sexual development. May be required for
CC       sporulation only at elevated temperatures. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the COP9 signalosome (CSN) complex.
CC       {ECO:0000269|PubMed:17470786}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Present in uninduced vegetative hyphae, induced
CC       conidiating cultures and in both conidiospores and ascospores.
CC       {ECO:0000269|PubMed:7551046}.
CC   -!- SIMILARITY: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; U18265; AAA85690.1; -; mRNA.
DR   EMBL; AACD01000061; EAA59831.1; -; Genomic_DNA.
DR   EMBL; BN001302; CBF75752.1; -; Genomic_DNA.
DR   RefSeq; XP_661227.1; XM_656135.1.
DR   AlphaFoldDB; Q00648; -.
DR   SMR; Q00648; -.
DR   DIP; DIP-60931N; -.
DR   IntAct; Q00648; 4.
DR   STRING; 162425.CADANIAP00005117; -.
DR   EnsemblFungi; CBF75752; CBF75752; ANIA_03623.
DR   EnsemblFungi; EAA59831; EAA59831; AN3623.2.
DR   GeneID; 2873045; -.
DR   KEGG; ani:AN3623.2; -.
DR   VEuPathDB; FungiDB:AN3623; -.
DR   eggNOG; KOG3250; Eukaryota.
DR   HOGENOM; CLU_054426_0_0_1; -.
DR   InParanoid; Q00648; -.
DR   OMA; GTYKQFR; -.
DR   OrthoDB; 1396757at2759; -.
DR   Proteomes; UP000000560; Chromosome II.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0008180; C:COP9 signalosome; IDA:AspGD.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070791; P:cleistothecium development; IPI:AspGD.
DR   InterPro; IPR045237; COPS7/eIF3m.
DR   InterPro; IPR000717; PCI_dom.
DR   PANTHER; PTHR15350; PTHR15350; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..327
FT                   /note="COP9 signalosome complex subunit 7"
FT                   /id="PRO_0000314736"
FT   DOMAIN          4..165
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          233..260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          276..327
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        237..251
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   327 AA;  35332 MW;  8E4472488AE01893 CRC64;
     MDQVHHRALD ALQSFIALTD SSSATSPRYI ASIITNATSS PHTYVFAELL ERPAVQALRS
     PDTPAEFQSY LTLLEIFAWG TWQDYQQTPN LPPLSEEQAR KLRLLTLLSL ASTIKPLTYE
     ALMTSLSLSA PSELESLVTT AIYSSLITGR LSPATNPPTV NVTSVAPLRD VKPSSLPTMI
     STLTAWEARC GSVISDIETE IAKIRADSAQ RRQKEHARAV AIEKTLEKWN AEGGEQLQGG
     NPGQGQGQGQ GGLGKNAGWK PRDLSTAMFE RGFFGGGSNK REFDDDGYFD GGSSDFDQHG
     SGMDIDEGAG ARASGARHSK RFLGKKS