ID   CSN8_DANRE              Reviewed;         191 AA.
AC   Q7ZUZ0;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=COP9 signalosome complex subunit 8;
DE            Short=Signalosome subunit 8;
GN   Name=cops8; ORFNames=zgc:56319;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC       involved in various cellular and developmental processes. The CSN
CC       complex is an essential regulator of the ubiquitin (Ubl) conjugation
CC       pathway by mediating the deneddylation of the cullin subunits of E3
CC       ligase complexes, leading to modify the Ubl ligase activity (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the CSN complex, probably composed of cops1,
CC       cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
CC       {ECO:0000250|UniProtKB:Q99627}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSN8 family. {ECO:0000305}.
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DR   EMBL; BC046071; AAH46071.1; -; mRNA.
DR   EMBL; BC071487; AAH71487.1; -; mRNA.
DR   RefSeq; NP_956523.1; NM_200229.2.
DR   AlphaFoldDB; Q7ZUZ0; -.
DR   SMR; Q7ZUZ0; -.
DR   STRING; 7955.ENSDARP00000037304; -.
DR   PaxDb; Q7ZUZ0; -.
DR   Ensembl; ENSDART00000034686; ENSDARP00000037304; ENSDARG00000024846.
DR   Ensembl; ENSDART00000184506; ENSDARP00000151178; ENSDARG00000115974.
DR   GeneID; 393198; -.
DR   KEGG; dre:393198; -.
DR   CTD; 10920; -.
DR   ZFIN; ZDB-GENE-040426-982; cops8.
DR   eggNOG; KOG4414; Eukaryota.
DR   GeneTree; ENSGT00940000166277; -.
DR   HOGENOM; CLU_098091_1_1_1; -.
DR   InParanoid; Q7ZUZ0; -.
DR   OMA; DFSTRMV; -.
DR   OrthoDB; 1577916at2759; -.
DR   PhylomeDB; Q7ZUZ0; -.
DR   TreeFam; TF101150; -.
DR   Reactome; R-DRE-5696394; DNA Damage Recognition in GG-NER.
DR   Reactome; R-DRE-6781823; Formation of TC-NER Pre-Incision Complex.
DR   Reactome; R-DRE-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR   Reactome; R-DRE-8951664; Neddylation.
DR   PRO; PR:Q7ZUZ0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 9.
DR   Bgee; ENSDARG00000024846; Expressed in testis and 31 other tissues.
DR   GO; GO:0008180; C:COP9 signalosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0010387; P:COP9 signalosome assembly; IEA:InterPro.
DR   GO; GO:0000338; P:protein deneddylation; IEA:InterPro.
DR   InterPro; IPR033205; COP9_CSN8.
DR   InterPro; IPR033464; CSN8_PSD8_EIF3K.
DR   InterPro; IPR000717; PCI_dom.
DR   PANTHER; PTHR13339; PTHR13339; 1.
DR   Pfam; PF10075; CSN8_PSD8_EIF3K; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..191
FT                   /note="COP9 signalosome complex subunit 8"
FT                   /id="PRO_0000121011"
FT   DOMAIN          6..179
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   191 AA;  21546 MW;  7E36460743586020 CRC64;
     MPVCVMMAEL DEKLLLQFET QELEAPGGIA TPQVYSQLLV LYLLHNDMNN ARYLWKRIPQ
     AIKTANPEMA AIWAVGQRIW QRDFPGIYSA IAAYQWSESI LPVMEALRES TRRRAYGLVA
     QAYTSISAED FAAFVGYSVE EAVKGVVSHG WQADPNTRMI MPQKPDPPPV SLVPNEQQLA
     RLTDYVAFLE N