ID   CSN8_DICDI              Reviewed;         196 AA.
AC   Q75K24; Q552P7;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=COP9 signalosome complex subunit 8;
DE            Short=Signalosome subunit 8;
GN   Name=csn8; ORFNames=DDB_G0275471;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND IDENTIFICATION IN THE CSN COMPLEX.
RX   PubMed=16781008; DOI=10.1016/j.ejcb.2006.04.006;
RA   Rosel D., Kimmel A.R.;
RT   "The COP9 signalosome regulates cell proliferation of Dictyostelium
RT   discoideum.";
RL   Eur. J. Cell Biol. 85:1023-1034(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC       involved in various cellular and developmental processes. The CSN
CC       complex is an essential regulator of the ubiquitin (Ubl) conjugation
CC       pathway by mediating the deneddylation of the cullin subunits of E3
CC       ligase complexes, leading to modify the Ubl ligase activity.
CC   -!- SUBUNIT: Component of the CSN complex. The holocomplex is comprised of
CC       8 subunits csn1-8. In the complex, it probably interacts directly with
CC       csn5 and csn8. {ECO:0000269|PubMed:16781008}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSN8 family. {ECO:0000305}.
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DR   EMBL; DQ309436; ABC46700.1; -; mRNA.
DR   EMBL; AAFI02000013; EAL69486.1; -; Genomic_DNA.
DR   RefSeq; XP_643634.1; XM_638542.1.
DR   AlphaFoldDB; Q75K24; -.
DR   SMR; Q75K24; -.
DR   STRING; 44689.DDB0233107; -.
DR   PaxDb; Q75K24; -.
DR   EnsemblProtists; EAL69486; EAL69486; DDB_G0275471.
DR   GeneID; 8620221; -.
DR   KEGG; ddi:DDB_G0275471; -.
DR   dictyBase; DDB_G0275471; csn8.
DR   eggNOG; KOG4414; Eukaryota.
DR   HOGENOM; CLU_098091_1_1_1; -.
DR   InParanoid; Q75K24; -.
DR   OMA; DFSTRMV; -.
DR   PhylomeDB; Q75K24; -.
DR   Reactome; R-DDI-5696394; DNA Damage Recognition in GG-NER.
DR   Reactome; R-DDI-6781823; Formation of TC-NER Pre-Incision Complex.
DR   Reactome; R-DDI-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR   Reactome; R-DDI-8951664; Neddylation.
DR   PRO; PR:Q75K24; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0008180; C:COP9 signalosome; IPI:dictyBase.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0010387; P:COP9 signalosome assembly; IEA:InterPro.
DR   GO; GO:0000338; P:protein deneddylation; IEA:InterPro.
DR   InterPro; IPR033205; COP9_CSN8.
DR   InterPro; IPR033464; CSN8_PSD8_EIF3K.
DR   InterPro; IPR000717; PCI_dom.
DR   PANTHER; PTHR13339; PTHR13339; 1.
DR   Pfam; PF10075; CSN8_PSD8_EIF3K; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT   CHAIN           1..196
FT                   /note="COP9 signalosome complex subunit 8"
FT                   /id="PRO_0000327773"
FT   DOMAIN          10..177
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   196 AA;  22508 MW;  13CA6EAD80D541E7 CRC64;
     MAFTEIANLI SSKNFKAILD YCQRQEIESK NIDLIKSYYG VYLLSYLINN DLINAKHLWK
     RIPNDFKQSN QQLKNIYTII KSISQTNPTI TYTSLSINIG DDYTPFITTL KENFQQRTFE
     LISNAYSSIT VNDCSSYLGI SPEDTIKFTT SKCWEHDKAS NTLKPVPIQK QSSELPTGNQ
     QIRSLTSYVL FLEKST